Evidence map›Paper›PMID 30464572›Full record

ArticleJournal of inflammation research2018

2LARTH

Ilaria Floris, Kurt Appel, Thorsten Rose, Beatrice Lejeune

Open access · goldAbstract read
In one paragraph

Article in Journal of inflammation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Active Substances from the Micro-Immunotherapy Medicine 2LC1International journal of molecular sciences · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Actives from the Micro-Immunotherapy Medicine 2LMIREGJournal of inflammation research · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ilaria FlorisClinical Affairs, Labo'Life France, Moutiers-Sous-Chantemerle, France, ilaria.floris@labolife.com.
Kurt AppelVivaCell Biotechnology GmbH, Denzlingen, Germany.
Thorsten RoseVivaCell Biotechnology GmbH, Denzlingen, Germany.
Beatrice LejeuneClinical Affairs, Labo'Life Belgium, Gembloux, Belgium.
Amer Sports (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumor necrosis factor-α (TNF-α) and IL-1β are 2 pro-inflammatory cytokines known to be involved in rheumatic diseases. The therapeutic strategy used in micro-immunotherapy (MI) to reduce chronic inflammation and attenuate pain consists in mainly targeting these 2 cytokines. 2LARTH PURPOSE: The aim of the study is to explore the effect of the MI medicine on TNF-α and IL-1β secretion in human primary enriched monocytes exposed to lipopolysaccharide (LPS). MATERIALS AND

methodsPlacebo and active globules were diluted in culture medium to test 5 lactose-saccharose globules concentrations (from 1.75 to 22 mM). Freshly isolated enriched monocytes from 6 healthy donors were treated with or without LPS (10 ng/mL), LPS+ placebo, or LPS+ 2LARTH

resultsThe medicine has significantly decreased the level of IL-1β secretion compared with placebo at these concentrations: 22 mM (

conclusionThe results indicate that the tested product exerts significant anti-inflammatory effects on human LPS-stimulated monocytes.

Indexed as

chronic inflammationhormesisrheumatic diseasesultra-low doses

Identifiers

PMID30464572
PMCPMC6211308
OpenAlexW2898452876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.