Evidence map›Paper›PMID 30464542›Full record

ArticleInfection and drug resistance2018

Entecavir add-on or switch-to pegylated interferon improves HBsAg clearance in HBe antigen negative chronic hepatitis B patients.

Lei Yan, Chuanwu Zhu, Jing Li, Liwen Chen, Yezhou Ding, Zhujun Cao, Kehui Liu, Lanyi Lin, Weiliang Tang, Qing Xie and 3 more

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. [Research progress on predictive indicators of a clinical cure for chronic hepatitis B].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. [The expert consensus on clinical cure (functional cure) of chronic hepatitis B].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Lei YanDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Chuanwu ZhuDepartment of Infectious Diseases, The Fifth People's Hospital of Suzhou, Jiangsu 215007, China.
Jing LiDepartment of Infectious Diseases, Huai-An Fourth People's Hospital, Jiangsu 223002, China.
Liwen ChenDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Yezhou DingDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Zhujun CaoDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Kehui LiuDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Lanyi LinDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Weiliang TangDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Qing XieDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Yumin XuDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Shisan BaoDiscipline of Pathology, School of Medical Sciences and Bosch Institute, Charles Perkin Centre, University of Sydney, Sydney, NSW, Australia, bob.bao@sydney.edu.au.
Hui WangDepartment of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, wanghuirj@163.com.
Shanghai Jiao Tong University · CNRuijin Hospital · CNHuai'an City Fourth People's Hospital · CNThe Fifth People’s Hospital of Suzhou · CNUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsChronic hepatitis B (CHB) patients rarely achieve hepatitis B surface antigen (HBsAg) loss with nucleoside/nucleotide analog therapy.

methodsIn this retrospective study, it was evaluated that the rate of HBsAg loss in the HBe antigen negative (HBeAg

resultsHBsAg clearance rate at week 48 was 9% (2/22), 15% (4/26), and 0% (0/53) (

conclusionIn summary, we demonstrated that PEG-IFN enhanced HBsAg loss in HBeAg

Indexed as

add-onchronic hepatitis BentecavirHBsAgPEG-IFNswitch-to

Identifiers

PMID30464542
PMCPMC6211310
OpenAlexW2898098241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.