Evidence map›Paper›PMID 30464454›Full record

ArticleInternational journal of nanomedicine2018

Biosafety evaluation of Janus Fe

Hong Su, Xin Song, Juan Li, Muhammad Zubair Iqbal, Samuel Selorm Fiati Kenston, Zhen Li, Aiguo Wu, Min Ding, Jinshun Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong SuDepartment of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China, zhaojinshun@nbu.edu.cn.
Xin SongDepartment of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China, zhaojinshun@nbu.edu.cn.
Juan LiKey Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, People's Republic of China.
Muhammad Zubair IqbalKey Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, People's Republic of China.
Samuel Selorm Fiati KenstonDepartment of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China, zhaojinshun@nbu.edu.cn.
Zhen LiDepartment of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China, zhaojinshun@nbu.edu.cn.
Aiguo WuKey Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, People's Republic of China.
Min DingToxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA.
Jinshun ZhaoDepartment of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China, zhaojinshun@nbu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNewly synthesized Janus-structured Fe

methodsIn this study, the biosafety of both Janus Fe

resultsThe results show that only a slight Ti element accumulation in the heart, spleen, and liver could be found in the Janus Fe

conclusionOur results showed that under a low dose (5 mg/kg), both NP types had no significant toxicity in rats. Janus NPs certainly seem less toxic than TiO

Indexed as

AnimalsBody WeightInjections, IntravenousLiverLungMaleNanoparticlesOrgan SizeParticle SizeRats, Sprague-DawleySignal TransductionSpleenTitaniumTitaniumtitanium dioxideaccumulationbiodistributionFe3O4-TiO2 NPsICP-MSinductively coupled plasma mass spectrometryJanus structure NPsnanomedicineTiO2 NPs

Identifiers

PMID30464454
PMCPMC6217909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.