Observational studyInternational journal of chronic obstructive pulmonary disease
Improvement in hypercapnia does not predict survival in COPD patients on chronic noninvasive ventilation.
Observational study in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Hypercapnia at admission, regardless of acidosis, may worsen the outcome of hospitalised patients with chronic obstructive pulmonary disease exacerbations.Internal and emergency medicine · 2026Article
- Chronic noninvasive ventilation in COPD: towards the identification of a responder phenotype.ERJ open research · 2025Article
- Telemonitoring for the follow-up of home noninvasive ventilation: a promising future with ongoing challenges.ERJ open research · 2025Article
- The Effects of Home High-Flow Nasal Cannula Oxygen Therapy on Clinical Outcomes in Patients with Severe COPD and Frequent Exacerbations.Journal of clinical medicine · 2025Article
- Control of hypercapnia and mortality in home mechanical ventilation: the population-based DISCOVERY study.ERJ open research · 2024Article
- Does PaCOHeliyon · 2024Article
- Home noninvasive ventilation in severe COPD: in whom does it work and how?ERJ open research · 2024Article
- A retrospective study of the role of hypercapnia in patients with acromegaly.BMC pulmonary medicine · 2023Article
- Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation.BMC pulmonary medicine · 2022Observational
- Extracorporeal COThorax · 2020Article
- Home mechanical ventilation: quality of life patterns after six months of treatment.BMC pulmonary medicine · 2020Observational
- Article
- Trends in the Use and Outcomes of Mechanical Ventilation among Patients Hospitalized with Acute Exacerbations of COPD in Spain, 2001 to 2015.Journal of clinical medicine · 2019Article
- The Effects of Low Pressure Domiciliary Non-Invasive Ventilation on Clinical Outcomes in Patients with Severe COPD Regardless Having Hypercapnia.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt has recently been shown that chronic noninvasive ventilation (NIV) improves a number of outcomes including survival, in patients with stable hypercapnic COPD. However, the mechanisms responsible for these improved outcomes are still unknown. The aim of the present study was to identify parameters associated with: 1) an improved arterial partial pressure of carbon dioxide (PaCO PATIENTS AND
methodsData from 240 COPD patients treated with chronic NIV were analyzed. Predictors for the change in PaCO
resultsA higher level of bicarbonate before NIV initiation, the use of higher inspiratory ventilator pressures, the presence of anxiety symptoms, and NIV initiated following an exacerbation compared to NIV initiated in stable disease were associated with a larger reduction in PaCO
conclusionPatients with anxiety symptoms and a high bicarbonate level at NIV initiation are potentially good responders in terms of an improvement in hypercapnia. Also, higher inspiratory ventilator pressures are associated with a larger reduction in PaCO
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