Observational studyInternational journal of chronic obstructive pulmonary disease
Influence of the type of emphysema in the relationship between COPD and lung cancer.
Observational study in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- CT-defined Emphysema Morphology as a Predictor for Histological Subtypes of Lung Cancer: A Single-center Retrospective Study.Thoracic research and practice · 2026Article
- The association between emphysema detected on computed tomography and increased risk of lung cancer: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- Analysis of clinical characteristics and prognosis of lung cancer patients with CPFE or COPD: a retrospective study.BMC pulmonary medicine · 2024Article
- Quantifying emphysema in lung screening computed tomography with robust automated lobe segmentation.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- The adjusted impact of different severities of acute exacerbations and medications on the risk of developing dementia in COPD patients.BMC pulmonary medicine · 2023Article
- From COPD to Lung Cancer: Mechanisms Linking, Diagnosis, Treatment, and Prognosis.International journal of chronic obstructive pulmonary disease · 2022Review
- Article
- Lung emphysema and lung cancer: what do we know about it?Annals of translational medicine · 2020Review
- Endothelial dysfunction is not a predictor of outcome in chronic obstructive pulmonary disease.Respiratory research · 2020Article
- Article
- Discordant Quantitative and Visual CT Assessments in the Diagnosis of Emphysema.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThere are no studies analyzing the relationship between emphysema and lung cancer (LC). With this aim and in order to make some comparisons between different clinical variables, we carried out the present study.
methodsThis is a case-control study, patients with COPD and LC being the cases and subjects with stable COPD being the controls. Clinical and functional parameters, as well as the existence of radiological emphysema, were evaluated in a qualitative and quantitative way, using a radiological density of -950 Hounsfield units as a cutoff point in the images. The existence of several different types of emphysema (centrilobular, paraseptal, panacinar, or bullae) was analyzed, allowing patients to have more than one simultaneously. The extent to which lobes were involved was evaluated and the extension of emphysema was graduated for each type and location, following a quantitative scale. Differences between cases and controls were compared by using bivariate and multivariate analyzes with results expressed as OR and 95% CI.
resultsWe included 169 cases and 74 controls, 84% men with a FEV
conclusionPatients with COPD and paraseptal emphysema could be a risk group for the development of LC, especially adenocarcinoma subtype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.