Trial reportInternational journal of chronic obstructive pulmonary disease
Exercise performance and symptoms in lowlanders with COPD ascending to moderate altitude: randomized trial.
Trial report in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01875133 (Effect of Altitude on Exercise Performance of Patients With Chronic Obstructive Lung Disease), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Altitude on Exercise Performance of Patients With Chronic Obstructive Lung Disease
Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Effect of moderate altitude and nocturnal oxygen therapy on cerebrovascular function in patients with COPD: A randomized, crossover trial at 2048 m.Experimental physiology · 2026Trial
- The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled crossover trial.The European respiratory journal · 2024Trial
- Exercise Performance of Lowlanders with Chronic Obstructive Pulmonary Disease Acutely Exposed to 2048 m: A Randomized Cross-Over Trial.International journal of chronic obstructive pulmonary disease · 2023Trial
- Effect of nocturnal oxygen therapy on exercise performance of COPD patients at 2048 m: data from a randomized clinical trial.Scientific reports · 2021Trial
- Effect of Nocturnal Oxygen Therapy on Nocturnal Hypoxemia and Sleep Apnea Among Patients With Chronic Obstructive Pulmonary Disease Traveling to 2048 Meters: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Effect of Nocturnal Oxygen on Blood Pressure Response to Altitude Exposure in COPD - Data from a Randomized Placebo-Controlled Cross-Over Trial.International journal of chronic obstructive pulmonary diseaseTrial
- Exercise in acute and subacute hypoxic conditions: physiological responses affecting oxygen delivery and their applications to human health.The Journal of physiology · 2026Review
- Pulmonary haemodynamics by echocardiography over 3 days of acclimatization in lowlanders with chronic obstructive pulmonary disease travelling to 3100 m of high altitude.European heart journal open · 2025Article
- Peak Eccentric Cycling Exercise and Cardiorespiratory Responses to Normobaric Hypoxia Versus Normobaric Normoxia in Healthy Adults: A Randomized, Controlled Crossover Trial.Journal of clinical medicine · 2025Article
- Effects of acetazolamide on exercise performance in patients with COPD going to high altitude: randomised controlled trial.ERJ open research · 2025Article
- Exercise Dysfunction and Pulmonary Rehabilitation Strategies in COPD Patients at High-Altitudes: A Review.International journal of chronic obstructive pulmonary disease · 2025Review
- Reframing SpOFrontiers in physiology · 2025Review
- Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide.Frontiers in cardiovascular medicine · 2025Article
- Sleep at high altitude: A bibliometric study and visualization analysis from 1992 to 2022.Heliyon · 2024Article
- Article
- Counseling Patients with Chronic Obstructive Pulmonary Disease Traveling to High Altitude.High altitude medicine & biology · 2023Article
- Hypoxia-altitude simulation test to predict altitude-related adverse health effects in COPD patients.ERJ open research · 2023Article
- Validation of Noninvasive Assessment of Pulmonary Gas Exchange in Patients with Chronic Obstructive Pulmonary Disease during Initial Exposure to High Altitude.Journal of clinical medicine · 2023Article
- Changes in vital signs, ventilation mode, and catecholamine use during intensive care aeromedical evacuation flights.Frontiers in public health · 2023Article
- Adaptation and altitude sickness: A 40-year bibliometric analysis and collaborative networks.Frontiers in public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effects of altitude travel on exercise performance and symptoms in lowlanders with COPD.
designRandomized crossover trial.
settingUniversity Hospital Zurich (490 m), research facility in mountain villages, Davos Clavadel (1,650 m) and Davos Jakobshorn (2,590 m).
participantsForty COPD patients, Global Initiative for Obstructive Lung Disease (GOLD) grade 2-3, living below 800 m, median (quartiles) age 67 y (60; 69), forced expiratory volume in 1 second 57% predicted (49; 70).
interventionTwo-day sojourns at 490 m, 1,650 m, and 2,590 m in randomized order. OUTCOME MEASURES: Six-minute walk distance (6MWD), cardiopulmonary exercise tests, symptoms, and other health effects.
resultsAt 490 m, days 1 and 2, median (quartiles) 6MWD were 558 m (477; 587) and 577 m (531; 629). At 2,590 m, days 1 and 2, mean changes in 6MWD from corresponding day at 490 m were -41 m (95% CI -51 to -31) and -40 m (-53 to -27), n=40,
conclusionDuring sojourns at 1,650 m and 2,590 m, lowlanders with moderate to severe COPD experienced a mild reduction in exercise performance and nearly one quarter required oxygen therapy or descent to lower altitude because of adverse health effects. The findings may help to counsel COPD patients planning altitude travel. REGISTRATION: ClinicalTrials.gov: NCT01875133.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.