ArticleClinical ophthalmology (Auckland, N.Z.)2018
Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma.
Article in Clinical ophthalmology (Auckland, N.Z.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Comparison of Macular Ganglion Cell-Inner Plexiform Layer Thickness and Sectoral Ratio Asymmetry Among Different Glaucoma Types.Diagnostics (Basel, Switzerland) · 2026Article
- Structural and functional differentiation between compressive and glaucomatous optic neuropathy.Scientific reports · 2022Article
- Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography.Investigative ophthalmology & visual science · 2020Article
- Macular imaging with optical coherence tomography in glaucoma.Survey of ophthalmologyReview
- Quantification of the Peripapillary Microvasculature in Eyes with Glaucomatous Paracentral Visual Field Loss.Ophthalmology. GlaucomaArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe evaluated macular ganglion cell asymmetry as a tool for diagnosing paracentral scotoma (PCS) in early glaucoma. PATIENTS AND
methodsThis prospective study compared 58 patients with early glaucoma and PCS to 58 age-matched control individuals. All glaucomatous eyes had scotoma within the central 12 degrees of fixation and confined to one hemifield. We measured circumpapillary retinal nerve fiber layer (cpRNFL) thickness, macular ganglion cell-inner plexiform layer (GCIPL) thickness, and optic nerve head (ONH) parameters with Cirrus spectral domain optical coherence tomography. Macular ganglion cell asymmetry was expressed as the absolute differences and the ratios between the inferior and superior hemispheres, inferotemporal (IT) and superotemporal (ST) areas, IT and superonasal (SN) areas, IT and inferonasal (IN) areas, and ST and IN areas. The asymmetry index was the absolute log
resultsAll GCIPL parameters and most cpRNFL parameters were significantly lower in early glaucoma than in controls. The best discriminating parameters were inferior RNFL thickness, average RNFL thickness, and minimum GCIPL thickness. The macular ganglion cell asymmetry parameters with the largest AUROCs were the log IT/ST index, the absolute difference in IT-ST GCIPL thicknesses, and the log IT/SN index. Performance was comparable between the log IT/ST index and the cpRNFL (inferior RNFL thickness,
conclusionThe IT/ST asymmetry index may be useful as a new parameter for detecting structural changes in glaucoma patients with PCS.
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