ArticleNature2018
Helios is a key transcriptional regulator of outer hair cell maturation.
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 2% of its field
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty.PLoS genetics · 2020Pooled it
- Helios is critical for Treg effector differentiation in adipose autoimmunity.The Journal of experimental medicine · 2026Article
- CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice.iScience · 2026Article
- The Roles of Tbx2 in Cochlear Development and Auditory Function.Neuroscience bulletin · 2026Article
- Age outweighs route for AAV-PHP.eB transgene distribution via inner ear delivery.Drug delivery and translational research · 2026Article
- Multi-scale analysis reveals key targets mediating BPA-induced sensorineural hearing loss.Medicine · 2026Article
- Spontaneous Calcium Signalling in the Developing Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells.Neuroscience bulletin · 2026Article
- Single-Cell Profiling of the Developing Organ of Corti Identifies Etv4/5/1 as Key Regulators of Pillar Cell Identity.bioRxiv : the preprint server for biology · 2026Article
- Molecular heterogeneity of the non-human primate cochlea.Nature communications · 2026Article
- Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- prdm1a drives a fate switch between hair cells of different mechanosensory organs.Nature communications · 2025Article
- AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling.Science China. Life sciences · 2025Article
- Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells.bioRxiv : the preprint server for biology · 2025Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.Nature communications · 2025Article
- Helios-Illuminating the way for lymphocyte self-control.Immunology · 2025Review
- Mechanisms driving the functional maturation of the developing mammalian auditory pathway.Current topics in developmental biology · 2025Review
- AAV-regulatedMolecular therapy. Nucleic acids · 2024Article
- Co-option of the trichome-forming network initiated the evolution of a morphological novelty in Drosophila eugracilis.Current biology : CB · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 7 institutions in 3 countries.
Lauren ChessumMammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK.
Maggie S MaternDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Michael C KellyNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Stuart L JohnsonDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Yoko OgawaDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Beatrice MilonDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Mark McMurrayDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Elizabeth C DriverNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Andrew ParkerMammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK.
Yang SongInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Gemma CodnerMary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK.
Christopher T EsapaMammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK.
Jack PrescottMammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK.
Graham TrentDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Sara WellsMary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK.
Abigail K DragichDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.
Gregory I FrolenkovDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.
Matthew W KelleyNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Walter MarcottiDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Steve D M BrownMammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK.
Ran ElkonDepartment of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Michael R BowlMammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK. m.bowl@har.mrc.ac.uk.
Ronna HertzanoDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. rhertzano@som.umaryland.edu.
Mary Lyon Centre at MRC Harwell · GBUniversity of Maryland, Baltimore · USNational Institutes of Health · USUniversity of Kentucky · USUniversity of Sheffield · GBNational Institute on Deafness and Other Communication Disorders · USTel Aviv University · IL
Funding
Hair Cell Development in the Mammalian CochleaZIADC000059 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KELLEY, MATTHEW · 2009 to 2025
$41.8MAUTOSOMAL DOMINANT NONSYNDROMIC HEARING LOSSR01DC003544 · NIDCD · UNIVERSITY OF IOWA · PI SMITH, RICHARD J.H. · 1998 to 2017
$7.8MCOMPARATIVE AND EVOLUTIONARY BIOLOGY OF HEARINGT32DC000046 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI Catherine Emily Carr, Matthew J. Goupell · 1994 to 2026
$7.5MCell Type Specific Transcriptional Cascades in Inner Ear DevelopmentR01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HERTZANO, RONNA · 2015 to 2022
$3.6MRepair of mechano-electrical transduction in mammalian auditory hair cellsR01DC014658 · NIDCD · UNIVERSITY OF KENTUCKY · PI FROLENKOV, GREGORY I · 2015 to 2019
$2.0MHair Cell Development in the Mammalian CochleaZ01DC000059 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KELLEY, MATTHEW W · 2000 to 2008
$1.9MCell Type Specific Transcriptional Cascades in Inner Ear DevelopmentU01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI AHMED, ZUBAIR M. · 2023 to 2025
$1.6MPOSTDOCTORAL RESEARCH TRAINING IN OTOLARYNGOLOGYT32DC000059 · NIDCD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ANDERSON, JOHN H · 1999 to 2003
$453kTo be or not to be_GFI1 as a critical factor in hair cell fate and survivalF31DC016218 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI MATERN, MAGGIE S. · 2017 to 2018
$60kIntramural NIH HHS Z01 DC000059Medical Research Council MC_U142684175Medical Research Council MC_UP_1502/1Medical Research Council MC_UP_1503/2NIDCD NIH HHS F31 DC016218NIDCD NIH HHS NIDCD DC000059NIDCD NIH HHS NIH T32DC00046NIDCD NIH HHS R01 DC003544NIDCD NIH HHS R01 DC013817NIDCD NIH HHS R01 DC014658NIDCD NIH HHS T32 DC000046NIDCD NIH HHS T32 DC000059NIDCD NIH HHS U01 DC013817Wellcome Trust 102892Wellcome Trust 102892/Z/13/Z
Abstract
The sensory cells that are responsible for hearing include the cochlear inner hair cells (IHCs) and outer hair cells (OHCs), with the OHCs being necessary for sound sensitivity and tuning
Indexed as
Transcription, GeneticAnimalsBase SequenceBiomarkersDNA-Binding ProteinsFemaleGene Expression Regulation, DevelopmentalHair Cells, Auditory, OuterMaleMiceMice, Inbred C57BLTranscription FactorsTranscriptomeBiomarkersDNA-Binding ProteinsTranscription FactorsZfpn1a2 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.