Evidence map›Paper›PMID 30464331›Full record

ReviewPediatric research2019

Preventing bronchopulmonary dysplasia: new tools for an old challenge.

María Álvarez-Fuente, Laura Moreno, Jane A Mitchell, Irwin K Reiss, Paloma Lopez, Dolores Elorza, Liesbeth Duijts, Alejandro Avila-Alvarez, Luis Arruza, Manuel Ramirez Orellana and 9 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Article
  3. Dynamic association between plasma interleukin-1 family concentrations and bronchopulmonary dysplasia in extremely premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  4. Article
  5. Less invasive surfactant administration in the delivery room: A quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Lung ultrasound score as a tool to predict severity of bronchopulmonary dysplasia in neonates born ≤25 weeks of gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Observational
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

María Álvarez-FuentePediatric Cardiology Department, Ramón y Cajal University Hospital, Madrid, Spain.
Laura MorenoDepartment of Pharmacology, School of Medicine, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Ciber Enfermedades Respiratorias (CIBERES), University Complutense of Madrid, Madrid, Spain.
Jane A MitchellDepartment of Cardiothoracic Pharmacology and Vascular Biology, Imperial College, National Heart and Lung Institute, London, UK.
Irwin K ReissDepartment of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Paloma LopezNeonatology Department, La Paz University Hospital, Madrid, Spain.
Dolores ElorzaNeonatology Department, La Paz University Hospital, Madrid, Spain.
Liesbeth DuijtsDepartment of Pediatrics, Divisions of Respiratory Medicine and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Alejandro Avila-AlvarezDepartment of Pediatrics, Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain.
Luis ArruzaNeonatology Department, Hospital Clínico San Carlos, Madrid, Spain.
Manuel Ramirez OrellanaDepartment of Pediatric Oncology, Unit for Cell and Gene Therapies at Hospital Universitario Niño Jesús, Madrid, Spain.
Eugenio BaraldiNeonatology Department, Azienda Ospidaliera De Padova, Padova, Italy.
Patrizia ZaramellaNeonatology Department, Azienda Ospidaliera De Padova, Padova, Italy.
Santiago RuedaDepartment of Pediatrics, Hospital Universitario Clinico San Carlos, Madrid, Spain.
Álvaro Gimeno-Díaz de AtauriDepartment of Pediatrics, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Hercília GuimarãesNeonatology Department, Hospital de São João Porto, O Porto, Portugal.
Gustavo RochaNeonatology Department, Hospital de São João Porto, O Porto, Portugal.
Elisa ProençaNeonatology Department, Hospital de São João Porto, O Porto, Portugal.
Bernard ThébaudDepartment of Pediatrics, Division of Neonatology, Children's Hospital of Eastern Ontario, and Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Maria Jesús Del CerroPediatric Cardiology Department, Ramón y Cajal University Hospital, Madrid, Spain. majecerro@yahoo.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in infants and presents as a consequence of preterm birth. Due to the lack of effective preventive and treatment strategies, BPD currently represents a major therapeutic challenge that requires continued research efforts at the basic, translational, and clinical levels. However, not all very low birth weight premature babies develop BPD, which suggests that in addition to known gestational age and intrauterine and extrauterine risk factors, other unknown factors must be involved in this disease's development. One of the main goals in BPD research is the early prediction of very low birth weight infants who are at risk of developing BPD in order to initiate the adequate preventive strategies. Other benefits of determining the risk of BPD include providing prognostic information and stratifying infants for clinical trial enrollment. In this article, we describe new opportunities to address BPD's complex pathophysiology by identifying prognostic biomarkers and develop novel, complex in vitro human lung models in order to develop effective therapies. These therapies for protecting the immature lung from injury can be developed by taking advantage of recent scientific progress in -omics, 3D organoids, and regenerative medicine.

Indexed as

Bronchopulmonary DysplasiaHumansInfantInfant, NewbornInfant, Newborn, DiseasesInfant, Premature

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.