ArticleNature2018
Protocadherin-1 is essential for cell entry by New World hantaviruses.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 125 citations in OpenAlex.
- Hantavirus preparedness at human-rodent interfaces: lessons from China's HFRS control and Andes virus transmission in mobile populations.Emerging microbes & infections · 2026Review
- Andes virus from the 2026Emerging microbes & infections · 2026Article
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- Temporal trends in critical care burden and outcomes of Andes virus-associated hantavirus cardiopulmonary syndrome: a national Chilean cohort.Intensive care medicine · 2026Article
- Cardiopulmonary Failure in Hantavirus Disease: Mechanisms, Recognition, and ECMO-Based Management.Viruses · 2026Review
- Human Orthohantavirus Infections: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Andes hantavirus - A primer.Npj viruses · 2026Article
- Why Andes hantavirus is not the next SARS-CoV-2: contrasting viral shedding, transmissibility and genomic patterns.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Article
- A Standardized workflow for Orthohantavirus production, detection, and antiviral screening.Virology journal · 2026Article
- Elucidating genes sufficient for viral entry into cells through sequential genome-wide CRISPR activation screens.bioRxiv : the preprint server for biology · 2026Article
- Pathogenicity and virulence of Rodent-Borne Orthohantaviruses.Virulence · 2025Review
- Hantavirus GnACS infectious diseases · 2025Article
- Article
- Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates.PLoS pathogens · 2025Article
- Expanding the bat toolbox: Carollia perspicillata bat cell lines and reagents enable the characterization of viral susceptibility and innate immune responses.PLoS biology · 2025Article
- Article
- Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes.Cell · 2025Article
- A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies.PLoS pathogens · 2025Article
- Puumala orthohantavirus: prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology.Frontiers in immunology · 2025Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 11 institutions in 7 countries.
Rohit K JangraDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Andrew S HerbertUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Rong LiDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
Lucas T JaeOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Lara M KleinfelterDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Megan M SloughDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Sarah L BarkerDonnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Pablo Guardado-CalvoInstitut Pasteur, Structural Virology Unit and CNRS UMR3569, Paris, France.
Gleyder Román-SosaInstitut Pasteur, Structural Virology Unit and CNRS UMR3569, Paris, France.
M Eugenia DieterleDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Ana I KuehneUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Nicolás A MuenaFundación Ciencia & Vida, Laboratorio de Virología Molecular, Santiago, Chile.
Ariel S WirchnianskiUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Elisabeth K NyakaturaDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
J Maximilian FelsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Melinda NgDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Eva MittlerDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
James PanDonnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Sushma BharrhanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Anna Z WecDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Jonathan R LaiDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Sachdev S SidhuDonnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Nicole D TischlerFundación Ciencia & Vida, Laboratorio de Virología Molecular, Santiago, Chile.
Félix A ReyInstitut Pasteur, Structural Virology Unit and CNRS UMR3569, Paris, France.
Jason MoffatDonnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Thijn R BrummelkampOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands. t.brummelkamp@nki.nl.
Zhongde WangDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA. zonda.wang@usu.edu.
John M DyeUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA. john.m.dye1.civ@mail.mil.
Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA. kartik.chandran@einstein.yu.edu.
Albert Einstein College of Medicine · USUnited States Army Medical Research Institute of Infectious Diseases · USUniversity of Toronto · CACentre National de la Recherche Scientifique · FRFundación Ciencia and Vida · CLUtah State University · USAdimab (United States) · USCanadian Institute for Advanced Research · CACeMM Research Center for Molecular Medicine · ATInstitut Pasteur · FRThe Netherlands Cancer Institute · NL
Funding
TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0MTraining in HIV/AIDS Pathogenesis; Basic and Translational ResearchT32AI007501 · NIAID · YESHIVA UNIVERSITY · PI PRASAD, VINAYAKA R. · 1995 to 2024
$6.6MGeographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1MDissecting the receptor-mediated infection mechanisms of hantavirusesR01AI132633 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHANDRAN, KARTIK · 2017 to 2021
$3.2MEngineered, multispecific antibodies as broad anti-filovirus therapeuticsR01AI125462 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LAI, JONATHAN R. · 2017 to 2020
$3.0MNIAID NIH HHS R01 AI125462NIAID NIH HHS R01 AI132633NIAID NIH HHS T32 AI007501NIAID NIH HHS T32 AI070117NIGMS NIH HHS T32 GM007491
Abstract
The zoonotic transmission of hantaviruses from their rodent hosts to humans in North and South America is associated with a severe and frequently fatal respiratory disease, hantavirus pulmonary syndrome (HPS)
Indexed as
Virus InternalizationAnimalsCadherinsEndothelial CellsFemaleHantavirus Pulmonary SyndromeHaploidyHost-Pathogen InteractionsHumansLungMaleMesocricetusOrthohantavirusProtein DomainsProtocadherinsSin Nombre virusCadherinsPCDH1 protein, humanProtocadherins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.