ArticleScientific reports2018
Cancellation of Bessel beam side lobes for high-contrast light sheet microscopy.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Phase-multiplexed continuous Bessel droplet for high-contrast, gapless volumetric two-photon microscopy.Biomedical optics express · 2026Article
- Polarization-engineered aberration-resilient light sheet microscopy.bioRxiv : the preprint server for biology · 2026Article
- Bessel beam side lobe suppression via non-degenerate two-photon excitation.Biomedical optics express · 2026Article
- A Single Sub-Millimetric Metasurface-Based Optical Element for Lattice Bessel Beam Excitation Enabling Brain Activity Recordings In Vivo.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Sidelobe suppressed Bessel beams for one-photon light-sheet microscopy.Biomedical optics express · 2024Article
- High-throughput volumetric mapping of synaptic transmission.Nature methods · 2024Article
- High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping.Biomedical optics express · 2022Article
- Engineering a better light sheet in an axicon-based system using a flattened Gaussian beam of low order.Journal of biophotonics · 2022Article
- Broadband generation of accelerating polygon beams with large curvature ratio and small focused spot using all-dielectric metasurfaces.Nanophotonics (Berlin, Germany) · 2022Article
- Incoherent superposition of polychromatic light enables single-shot nondiffracting light-sheet microscopy.Optics express · 2021Article
- Minutes-timescale 3D isotropic imaging of entire organs at subcellular resolution by content-aware compressed-sensing light-sheet microscopy.Nature communications · 2021Article
- Fluorescence imaging with tailored light.Nanophotonics (Berlin, Germany) · 2019Article
- Scattering Assisted Imaging.Scientific reports · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An ideal illumination for light sheet fluorescence microscopy entails both a localized and a propagation invariant optical field. Bessel beams and Airy beams satisfy these conditions, but their non-diffracting feature comes at the cost of the presence of high-energy side lobes that notably degrade the imaging contrast and induce photobleaching. Here, we demonstrate the use of a light droplet illumination whose side lobes are suppressed by interfering Bessel beams of specific k-vectors. Our droplet illumination readily achieves more than 50% extinction of the light distributed across the Bessel side lobes, providing a more efficient energy localization without loss in transverse resolution. In a standard light sheet fluorescence microscope, we demonstrate a two-fold contrast enhancement imaging micron-scale fluorescent beads. Results pave the way to new opportunities for rapid and deep in vivo observations of large-scale biological systems.
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Registered trials
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