ArticleHypertension research : official journal of the Japanese Society of Hypertension2019
Mechanisms of action of Panax notoginseng ethanolic extract for its vasodilatory effects and partial characterization of vasoactive compounds.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 21 citations in OpenAlex.
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- Naodesheng decoction regulating vascular function via G-protein-coupled receptors: network analysis and experimental investigations.Frontiers in pharmacology · 2024Article
- Article
- Bioactive Natural Products against Systemic Arterial Hypertension: A Past 20-Year Systematic and Prospective Review.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Chemical components of ginseng, their biotransformation products and their potential as treatment of hypertension.Molecular and cellular biochemistry · 2021Review
- 25-OH-PPD inhibits hypertrophy on diabetic cardiomyopathy via the PI3k/Akt/GSK-3β signaling pathway.Experimental and therapeutic medicine · 2020Article
- Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury.Journal of immunology research · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Panax notoginseng is the most valuable medicinal plant and has been used clinically for more than two thousand years to treat various diseases, including hypertension. Previous studies claimed that different isolated compounds from P. notoginseng are involved in different pathways for vasodilation. It is strongly believed that these vasodilating compounds might act synergistically in contributing vasodilatory effects via holistic signaling pathways. The present study aims to evaluate the vasodilatory effect and mechanism of action employed by the crude extract of P. notoginseng. The fingerprint of P. notoginseng was developed using tri-step FTIR and HPTLC. The contents of Rg1 and Rb1 in the active extract (PN95) were further quantified via HPTLC. The vasodilatory effect of PN95 was evaluated using an in vitro aortic ring model. The results showed that PN95 contains a high amount of Rg1 and Rb1, 25.9 and 13.6%, respectively. The vasodilatory effect of PN95 was elicited via the NO/sGC/cGMP and β
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