ArticleScientific reports2018
Exposure history, post-exposure prophylaxis use, and clinical characteristics of human rabies cases in China, 2006-2012.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human rabies despite post-exposure prophylaxis: a systematic review of fatal breakthrough infections after zoonotic exposures.The Lancet. Infectious diseases · 2023Pooled it
- Targeting the Cav1.2-KCa1.1 axis prevents rabies virus internalization and protects against lethal infection.PLoS pathogens · 2026Article
- Nationwide registry-based analysis of rabies exposures in Iran: Epidemiological patterns and post-exposure prophylaxis adherence.PLoS neglected tropical diseases · 2026Article
- Survey on the current status of rabies post-exposure prophylaxis clinics construction and the surveillance of rabies-exposed individuals in China, 2022.PLoS neglected tropical diseases · 2026Article
- Epidemiological Characteristics of Human Rabies in Chongqing, China, 2016-2024.Tropical medicine and infectious disease · 2026Article
- Biological barriers underlying the extremely high fatality of symptomatic rabies: neuroinvasion, immune evasion, and blood-brain barrier restriction.Frontiers in immunology · 2026Review
- Article
- Exploring one health-based strategies for rabies elimination: Overview and future prospects.PLoS neglected tropical diseases · 2025Review
- Characteristics, Post-exposure prophylaxis usage, and clinical features of Chinese human rabies cases, 2016-2020.PLoS neglected tropical diseases · 2025Article
- Metagenomic next-generation sequencing for etiological diagnosis of an unexpected rabies case with unclear exposure history.BMC infectious diseases · 2025Article
- Rabies in Cats-An Emerging Public Health Issue.Viruses · 2024Review
- Epidemiological characteristics of human rabies cases reported by sites in China from 2006 to 2022.BMC infectious diseases · 2024Article
- Spatial accessibility and inequality analysis of rabies-exposed patients to rabies post-exposure prophylaxis clinics in Guangzhou City, China.International journal for equity in health · 2024Article
- Puppies as the primary causal animal for human rabies cases: three-year prospective study of human rabies in the Philippines.Frontiers in microbiology · 2024Article
- Progress towards dog-mediated rabies elimination in PR China: a scoping review.Infectious diseases of poverty · 2023Article
- The Determinants of Non-compliance on Rabies Vaccination in North-West Peninsular Malaysia.Journal of epidemiology and global health · 2023Article
- Factors Associated with Dog Rabies Immunization in Changsha, China: Results of a Cross-Sectional Cluster Survey, 2015-2021.Viruses · 2022Article
- Investigate Non-EPI Vaccination Recommendation Practice from a Socio-Ecological Perspective: A Mixed-Methods Study in China.Vaccines · 2022Article
- Clinical, epidemiological, and spatial features of human rabies cases in Metro Manila, the Philippines from 2006 to 2015.PLoS neglected tropical diseases · 2022Article
- Epidemiological Study of Outpatients in Rabies Post-Exposure Prophylaxis Clinics - Tianjin Municipality, China, 2020.China CDC weekly · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Rabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in China from 2006 to 2012. Most cases (n = 7,947; 92.0%) were caused by animal bites; 5,800 (55.8%) and 2,974 (28.6%) exposures were from domestic and free-roaming dogs, respectively. Only 278 (4.8%) of these domestic dogs had previously received rabies vaccination. Among all cases, 5,927 (59.7%) cases had category III wounds, 1,187 (11.7%) cases initiated the rabies PEP vaccination and 234 (3.9%) cases with category III wounds received rabies immunoglobulin. In our adjusted logistic regression model, male cases (adjusted odds ratio [aOR] = 1.25, 95% confidence interval [CI]: 1.09-1.44) and farmers (aOR = 1.39, 95% CI: 1.10-1.77) and person older than 55 years (aOR = 1.48, 95% CI: 1.01-2.17) were less likely than females and persons in other occupations or younger than 15 years to initiate PEP vaccination. The median incubation period was 66 days (interquartile range (IQR): 33-167 days). To reduce the number of human deaths due to rabies, rabies prevention campaigns targeting males and farmers and older people should be conducted. Increasing routine rabies vaccination among domestic dogs will be essential in the long term.
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