Evidence map›Paper›PMID 30464089›Full record

ArticleThe Journal of veterinary medical science2019

Hatano rats are a suitable metabolic syndrome model for studying feeding behavior, blood pressure levels, and percent body fat.

Anna Isobe, Tsutomu Shimada, Masaki Aburada, Rie Yanagisawa, Tomoyoshi Sakawa, Takahiro Nakamura, Toshiyuki Himi, Ryo Ohta, Maiko Kawaguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna IsobeLab of Animal Behavior and Environmental Science, Graduate School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama, Kawasaki, Kanagawa 214-8571, Japan.
Tsutomu ShimadaDepartment of Hospital Pharmacy, University Hospital, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan.
Masaki AburadaMusashino University, 1-1-20, Shinmachi, Nishitokyo, Tokyo 202-8585, Japan.
Rie YanagisawaCenter for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
Tomoyoshi SakawaFaculty of Pharmaceutical Sciences, Teikyo Heisei University, 4-21-2 Nakano, Nakano, Tokyo 164-8530, Japan.
Takahiro NakamuraFaculty of Pharmaceutical Sciences, Teikyo Heisei University, 4-21-2 Nakano, Nakano, Tokyo 164-8530, Japan.
Toshiyuki HimiMusashino University, 1-1-20, Shinmachi, Nishitokyo, Tokyo 202-8585, Japan.
Ryo OhtaHatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano, Kanagawa 257-8523, Japan.
Maiko KawaguchiLab of Animal Behavior and Environmental Science, Graduate School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama, Kawasaki, Kanagawa 214-8571, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, metabolic syndrome is a worldwide concern. Thus, it is imperative to understand the mechanism of metabolic syndrome by establishing various metabolic syndrome models. In this study, we used Hatano high-avoidance animals (HAA) and low-avoidance animals (LAA), both derived from Sprague-Dawley rats by selective breeding to determine high- or low-avoidance rates in shuttle-box active avoidance tests. HAA and LAA rats have some strain differences related to eating and appetite. Therefore, we determined whether Hatano rats could be used as a metabolic syndrome model. We compared food intake, body weights, blood pressure levels, plasma component levels, and fat contents between HAA and LAA rats. The HAA rats showed more active eating, higher blood pressure, higher percentage fat, and higher triglyceride levels than the LAA rats-these features correspond to some of the risk factors associated with metabolic syndrome. Our study suggests that HAA rats can be considered as a metabolic syndrome model by focusing on their feeding behavior, blood pressure levels, and percent body fat.

Indexed as

Disease Models, AnimalMetabolic SyndromeRats, Inbred StrainsAnimalsAvoidance LearningBody WeightEatingRatsblood pressurefeeding behaviorHatano ratmetabolic syndromemodel animal

Identifiers

PMID30464089
PMCPMC6361638

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.