Evidence map›Paper›PMID 30464022›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2019

Trends in Pediatric Central Nervous System Tumor Incidence in the United States, 1998-2013.

Diana R Withrow, Amy Berrington de Gonzalez, Clara J K Lam, Katherine E Warren, Meredith S Shiels

Abstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Role of surgery in the treatment of pediatric low-grade glioma with various degrees of brain stem involvement.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  6. Trends in pediatric CNS tumors in Armenia: a multicenter retrospective study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Medulloblastoma: Current Perspectives and Recent Advances.Brain tumor research and treatment · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Up-Regulation ofCell journal · 2021
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Diana R WithrowDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland. diana.withrow@nih.gov.ORCID 0000-0002-9757-040X
Amy Berrington de GonzalezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Clara J K LamDivision of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland.
Katherine E WarrenCenter for Cancer Research, NCI, Bethesda, Maryland.
Meredith S ShielsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
National Cancer Institute · USCenter for Cancer Research · US

Funding

Early Clinical Trials for Children with CNS TumorsZIABC011447 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WARREN, KATHERINE E · 2012 to 2019
$2.1M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

backgroundBrain and other central nervous system (CNS) cancers are the leading cause of U.S. pediatric cancer mortality. Incidence trends can provide etiologic insight. We report trends in incidence rates of pediatric malignant CNS cancers and pilocytic astrocytoma (nonmalignant but historically registered) in the United States.

methodsAge-standardized incidence rates and annual percent changes (APC) in rates during 1998 to 2013 were calculated for children aged 0 to 19, stratified by subtype, age, sex, and for gliomas, histology and location. We estimated the absolute change in number of cases diagnosed U.S.-wide during 2013 compared with the expected number of cases had 1998 rates remained stable.

resultsRates of all pediatric malignant CNS cancer combined (

conclusionsThe gradual changes in incidence we observed for specific types of pediatric CNS cancers are likely due to a combination of changes in classification and diagnosis and true changes in CNS cancer. IMPACT: Continued surveillance of pediatric CNS tumors should remain a priority, given their significant contribution to pediatric cancer-related deaths.

Indexed as

AdolescentAdultCentral Nervous System NeoplasmsChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMaleSEER ProgramTime FactorsUnited StatesYoung Adult

Identifiers

PMID30464022
PMCPMC6401271
OpenAlexW2900497817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.