Evidence map›Paper›PMID 30463981›Full record

ArticleJournal of virology2019

Increased Frequency of Virus Shedding by Herpes Simplex Virus 2-Infected Guinea Pigs in the Absence of CD4

Nigel Bourne, Clarice L Perry, Brianne N Banasik, Aaron L Miller, Mellodee White, Richard B Pyles, Hubert Schäfer, Gregg N Milligan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Analysis of lymphocyte T(CD4Infectious disease reports · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Nigel BourneDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Clarice L PerryDepartment of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA.
Brianne N BanasikDepartment of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA.
Aaron L MillerDepartment of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA.
Mellodee WhiteDepartment of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA.
Richard B PylesDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Hubert SchäferDepartment of Immunology, Robert Koch-Institute, Nordufer, Berlin, Germany.
Gregg N MilliganDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA gnmillig@utmb.edu.
The University of Texas Medical Branch at Galveston · USRobert Koch Institute · DE

Funding

Induction, maintenance, and function of genital tract-resident CD8+ T cellsR01AI107784 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MILLIGAN, GREGG N. · 2015 to 2019
$1.7M
NIAID NIH HHS R01 AI107784
6 · The paper itself

Abstract

Reactivation of herpes simplex virus 2 (HSV-2) results in infection of epithelial cells at the neuro-epithelial junction and shedding of virus at the epithelial surface. Virus shedding can occur in either the presence or absence of clinical disease and is usually of short duration, although the shedding frequency varies among individuals. The basis for host control of virus shedding is not well understood, although adaptive immune mechanisms are thought to play a central role. To determine the importance of CD4

Indexed as

AnimalsAntibodies, ViralAntibody-Producing CellsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleGuinea PigsHerpes SimplexHerpesvirus 2, HumanImmunity, CellularViral Envelope ProteinsVirus SheddingAntibodies, ViralViral Envelope ProteinsCD4+ T lymphocytegenital mucosaguinea pigHSV-2HSV-2 shedding

Identifiers

PMID30463981
PMCPMC6364026
OpenAlexW2900903728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.