Evidence map›Paper›PMID 30463965›Full record

ArticleJournal of virology2019

Defective Viral Genomes Alter How Sendai Virus Interacts with Cellular Trafficking Machinery, Leading to Heterogeneity in the Production of Viral Particles among Infected Cells.

Emmanuelle Genoyer, Carolina B López

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  15. A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations.Microbiology and molecular biology reviews : MMBR · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emmanuelle GenoyerDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Carolina B LópezDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA lopezca@upenn.edu.ORCID 0000-0002-7669-6572
University of Pennsylvania · US

Funding

Defective Viral genomes in RSV pathogenesisR01AI137062 · NIAID · WASHINGTON UNIVERSITY · PI Carolina B. Lopez · 2018 to 2026
$4.2M
A novel virus-derived adjuvantR01AI083284 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LOPEZ, CAROLINA B. · 2009 to 2017
$3.3M
FLIM system, resonant scanner, and UV laser for 2 photon microscopeS10RR027128 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2010 to 2010
$496k
Mechanism for virus persistence after acute infectionsR21AI127832 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LOPEZ, CAROLINA B. · 2017 to 2018
$443k
NCRR NIH HHS S10 RR027128NIAID NIH HHS R01 AI083284NIAID NIH HHS R01 AI137062NIAID NIH HHS R21 AI127832
6 · The paper itself

Abstract

Defective viral genomes (DVGs) generated during RNA virus replication determine infection outcome by triggering innate immunity, diminishing virulence, and, in many cases, facilitating the establishment of persistent infections. Despite their critical role during virus-host interactions, the mechanisms regulating the production and propagation of DVGs are poorly understood. Visualization of viral genomes using RNA fluorescent

Indexed as

A549 CellsAnimalsCell LineDefective VirusesGenome, ViralHumansIn Situ Hybridization, FluorescenceProtein TransportRNA, ViralRNA VirusesSendai virusVirionVirus AssemblyVirus ReplicationRNA, Viraldefective interfering particlesdefective viral genomesinfection heterogeneityparamyxovirusparticle production

Identifiers

PMID30463965
PMCPMC6364009
OpenAlexW2900584728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.