Evidence map›Paper›PMID 30463955›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Tissue-specific contributions of

Joshua J Emrick, Anubhav Mathur, Jessica Wei, Elena O Gracheva, Karsten Gronert, Michael D Rosenblum, David Julius

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. TRPV3 in skin thermosensation and temperature responses.The journal of physiological sciences : JPS · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Cytokines reprogram airway sensory neurons in asthma.bioRxiv : the preprint server for biology · 2024
    Article
  8. Genetic and Immunological Pathogenesis of Atopic Dermatitis.The Journal of investigative dermatology · 2024
    Review
  9. Special Issue "Molecular and Cellular Advances in Atopic Diseases".International journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Nobel somatosensations and pain.Pflugers Archiv : European journal of physiology · 2022
    Review
  13. The Epidermis: Redox Governor of Health and Diseases.Antioxidants (Basel, Switzerland) · 2021
    Review
  14. Review
  15. Molecular Signature of Pruriceptive MrgprA3The Journal of investigative dermatology · 2020
    Article
  16. Article
  17. Physiology and Pathophysiology of Itch.Physiological reviews · 2020
    Review
  18. Natural Autoantibodies in Chronic Pulmonary Diseases.International journal of molecular sciences · 2020
    Review
  19. Article
  20. The role of NaTheranostics · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joshua J EmrickDepartment of Physiology, University of California, San Francisco, CA 94143.
Anubhav MathurDepartment of Dermatology, University of California, San Francisco, CA 94143.
Jessica WeiVision Science Graduate Program, School of Optometry, University of California, Berkeley, CA 94720.
Elena O GrachevaDepartment of Physiology, University of California, San Francisco, CA 94143.
Karsten GronertVision Science Graduate Program, School of Optometry, University of California, Berkeley, CA 94720.
Michael D RosenblumDepartment of Dermatology, University of California, San Francisco, CA 94143.
David JuliusDepartment of Physiology, University of California, San Francisco, CA 94143; david.julius@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

Natural products as probes of the pain pathwayR35NS105038 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIUS, DAVID · 2018 to 2025
$9.0M
ASIC Channels and PainR01NS081115 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIUS, DAVID · 2012 to 2016
$1.9M
Regulatory Tissue Polymorphonuclear Leukocytes Determinants of Ocular Immune ResponsesR01EY026082 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI GRONERT, KARSTEN · 2016 to 2019
$1.5M
Dissecting the Role of Regulatory T cells in Epidermal Stem Cell DifferentiationK08AR070910 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATHUR, ANUBHAV NARAIN · 2017 to 2017
$189k
Mapping Orofacial Nociceptive Pathways and Alterations Due to InflammationF30DE023476 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EMRICK, JOSHUA JAMES · 2013 to 2016
$185k
NEI NIH HHS R01 EY026082NIAMS NIH HHS K08 AR070910NIDCR NIH HHS F30 DE023476NINDS NIH HHS R01 NS081115NINDS NIH HHS R35 NS105038
6 · The paper itself

Abstract

Atopic dermatitis (AD) is the most common skin disease in children. It is characterized by relapsing inflammation, skin-barrier defects, and intractable itch. However, the pathophysiology of itch in AD remains enigmatic. Here, we examine the contribution of

Indexed as

AnimalsDermatitis, AtopicGene DeletionHEK293 CellsHumansKeratinocytesMembrane ProteinsMiceOxidative StressPruritusSensory Receptor CellsSignal TransductionMembrane ProteinsTmem79 protein, humanTmem79 protein, mouseatopic dermatitisitchoxidative stressprostaglandin E2Tmem79

Identifiers

PMID30463955
PMCPMC6305010
OpenAlexW2900527309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.