ArticleBlood advances2018
Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia.
Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Practical guide to the diagnosis and management of heparin-induced thrombocytopenia.Hematology. American Society of Hematology. Education Program · 2024Review
- Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?Blood advances · 2023Article
- An institutional report of heparin induced thrombocytopenia type II in aneurysmal subarachnoid hemorrhage patients.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Heparin-induced thrombocytopenia: An illustrated review.Research and practice in thrombosis and haemostasis · 2023Article
- A machine-learning model for reducing misdiagnosis in heparin-induced thrombocytopenia: A prospective, multicenter, observational study.EClinicalMedicine · 2023Article
- Article
- Antibodies against Platelet Factor 4 and Their Associated Pathologies: From HIT/HITT to Spontaneous HIT-Like Syndrome, to COVID-19, to VITT/TTS.Antibodies (Basel, Switzerland) · 2022Review
- A Rare Case of Extensive Cerebral Venous Sinus Thrombosis Complicated by Heparin-Induced Thrombocytopenia.Case reports in hematology · 2022Article
- Heparin-induced thrombocytopenia and cardiovascular surgery.Hematology. American Society of Hematology. Education Program · 2021Article
- Clinical validation of immunoassay HemosIL® AcuStar HIT-IgG (PF4-H) in the diagnosis of Heparin-induced thrombocytopenia.Journal of thrombosis and thrombolysis · 2021Article
- Increased prevalence of heparin induced thrombocytopenia in COVID-19 patients.Thrombosis research · 2021Article
- Heparin-Induced Thrombocytopenia: A Review of New Concepts in Pathogenesis, Diagnosis, and Management.Journal of clinical medicine · 2021Review
- Heparin induced thrombocytopenia: position paper from the Italian Society on Thrombosis and Haemostasis (SISET).Blood transfusion = Trasfusione del sangue · 2021Article
- Pathogenesis of heparin-induced thrombocytopenia.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Soluble glycoprotein VI is a predictor of major bleeding in patients with suspected heparin-induced thrombocytopenia.Blood advances · 2020Article
- Diagnosing HIT: the need for speed.Blood · 2020Article
- The risk of major bleeding in patients with suspected heparin-induced thrombocytopenia.Journal of thrombosis and haemostasis : JTH · 2019Article
- Heparin-Induced Thrombocytopenia in Chronic Hemodialysis Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
- Fondaparinux for systemic anticoagulation during continuous hemofiltration in a patient with heparin-induced thrombocytopenia and limb ischemia - a case report.Hematology, transfusion and cell therapyArticle
- Prediction of Heparin Induced Thrombocytopenia (HIT) Using a Combination of 4Ts Score and Screening Immune Assays.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
The HIT Expert Probability (HEP) score compared favorably with the 4Ts score in a retrospective study. We assessed the diagnostic accuracy of the HEP score compared with the 4Ts score in a prospective cohort of 310 patients with suspected heparin-induced thrombocytopenia (HIT). A member of the clinical team calculated the HEP score and 4Ts score. An independent panel adjudicated HIT status based on a clinical summary as well as the results of HIT laboratory testing. The prevalence of HIT in the study population was 14.7%. At a cutoff of ≥3, the HEP score was 95.3% sensitive (95% confidence interval [CI], 84.2-99.4) and 35.7% specific (95% CI, 29.8-42.0) for HIT. A 4Ts score of ≥4 had a sensitivity of 97.7% (95% CI, 86.2-99.8) and specificity of 32.9% (95% CI, 27.2-39.1). The areas under the receiver operating characteristic (ROC) curves (AUCs) for the HEP score and 4Ts score were similar (0.81 [95% CI, 0.74-0.87] vs 0.76 [95% CI, 0.69-0.83];
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