Evidence map›Paper›PMID 30463901›Full record

ArticleGenes & development2018

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

Lei Yu, Natee Jearawiriyapaisarn, Mary P Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B Vojtek and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. New Gene Therapy Strategy for β-Thalassemia.Stem cell reviews and reports · 2026
    Review
  3. Article
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  7. BAP1 Loss Affords Lipotoxicity Resistance in Uveal Melanoma.Pigment cell & melanoma research · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Exploring epigenetic and microRNA approaches for γ-globin gene regulation.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Lei Yu *Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Natee Jearawiriyapaisarn *Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Mary P LeeDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Tomonori HosoyaDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Qingqing WuDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Greggory MyersDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Kim-Chew LimDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Ryo KuritaCell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.
Yukio NakamuraCell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.
Anne B VojtekDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Jean-François RualDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
James Douglas EngelDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
University of Michigan–Ann Arbor · USRIKEN BioResource Research Center · JPMahidol University · TH

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Improving HbF induction by inhibiting epigenetic target enzymesU01HL117658 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ENGEL, JAMES DOUGLAS, LAVELLE, DONALD · 2013 to 2017
$8.3M
Characterization of TR2 and TR4 homodimer and heterodimer transcriptional mechanisms during erythropoiesis.F32DK108493 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEE, MARY PATRICIA · 2016 to 2017
$115k
NCI NIH HHS P30 CA046592NHLBI NIH HHS U01 HL117658NIDDK NIH HHS F32 DK108493
6 · The paper itself

Abstract

Human globin gene production transcriptionally "switches" from fetal to adult synthesis shortly after birth and is controlled by macromolecular complexes that enhance or suppress transcription by

Indexed as

Binding SitesCell LineEnzyme ActivationEpigenesis, GeneticErythroid Cellsgamma-GlobinsGene Expression RegulationGene SilencingHEK293 CellsHumansK562 CellsNuclear Receptor Co-Repressor 1Nuclear Receptor Subfamily 2, Group C, Member 1Protein DomainsReceptors, SteroidReceptors, Thyroid HormoneBAP1 protein, humangamma-GlobinsNCOR1 protein, humanNR2C1 protein, humanNR2C2 protein, humanNuclear Receptor Co-Repressor 1Nuclear Receptor Subfamily 2, Group C, Member 1Receptors, SteroidReceptors, Thyroid HormoneTumor Suppressor ProteinsUbiquitin ThiolesteraseBAP1DRED complexfetal globin inductionNCoR1TR2TR4ubiquitin

Identifiers

PMID30463901
PMCPMC6295165
OpenAlexW2901881090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.