ArticleThe American journal of pathology1988
Immunocytochemical study of dystrophin in muscle cultures from patients with Duchenne muscular dystrophy and unaffected control patients.
Article in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 93 citations in OpenAlex.
- Antisense oligonucleotide selection scheme for rare Duchenne muscular dystrophy mutations: Application toMolecular therapy. Nucleic acids · 2026Article
- Regulatory Landscapes of Muscle Satellite Cells: From Mechanism to Application.International journal of stem cells · 2025Review
- Decoding the Gene Regulatory Network of Muscle Stem Cells in Mouse Duchenne Muscular Dystrophy: Revelations from Single-Nuclei RNA Sequencing Analysis.International journal of molecular sciences · 2023Article
- WDR5 is required for DUX4 expression and its pathological effects in FSHD muscular dystrophy.Nucleic acids research · 2023Article
- Modulation of Protein Quality Control and Proteasome to Autophagy Switch in Immortalized Myoblasts from Duchenne Muscular Dystrophy Patients.International journal of molecular sciences · 2018Article
- Expression levels of TGF-β1 and CTGF are associated with the severity of Duchenne muscular dystrophy.Experimental and therapeutic medicine · 2017Article
- Satellite Cells in Muscular Dystrophy - Lost in Polarity.Trends in molecular medicine · 2016Review
- Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division.Nature medicine · 2015Article
- In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis.eLife · 2015Article
- Spatio-Temporal Differences in Dystrophin Dynamics at mRNA and Protein Levels Revealed by a Novel FlipTrap Line.PloS one · 2015Article
- The chondrogenic response to exercise in the proximal femur of normal and mdx mice.BMC musculoskeletal disorders · 2010Article
- Expression of dog microdystrophin in mouse and dog muscles by gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
- Mechanisms of cell-mediated myocytotoxicity in the peripheral blood of patients with inflammatory myopathies.Journal of clinical immunology · 2001Article
- Lack of myoblasts migration between transplanted and host muscles of mdx and normal mice.Journal of muscle research and cell motility · 1996Article
- High efficiency of muscle regeneration after human myoblast clone transplantation in SCID mice.The Journal of clinical investigation · 1994Article
- Heterokaryon myotubes with normal mouse and Duchenne nuclei exhibit sarcolemmal dystrophin staining and efficient intracellular free calcium control.Molecular biology of the cell · 1993Article
- Size and localization of dystrophin molecule: immunoelectron microscopic and freeze etching studies of muscle plasma membranes of murine skeletal myofibers.Acta neuropathologica · 1993Article
- Ca2+ levels in myotubes grown from the skeletal muscle of dystrophic (mdx) and normal mice.The Journal of physiology · 1993Article
- Localization of dystrophin gene transcripts during mouse embryogenesis.The Journal of cell biology · 1992Article
- Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle.The Journal of cell biology · 1991Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Using immunocytochemical methods, the localization of dystrophin, the gene product affected in Duchenne muscular dystrophy (DMD) in aneural, differentiating human muscle cultures, was studied. Dystrophin was not demonstrable in undifferentiated myoblasts from control patients and from two patients with DMD. After myoblast fusion, the protein was found in circumscribed sarcoplasmic patches, in the perinuclear area, and along the surface of all normal multinucleate myotubes, with more mature myotubes showing predominantly sarcolemmal distribution. There was no staining in myotubes from one DMD patient and only faint diffuse fluorescence in myotubes from the second affected boy, however. These data provide further evidence that dystrophin is a sarcolemma-associated protein, that it is developmentally regulated, and that it is absent or greatly reduced in quantity in skeletal muscle cultures from patients with DMD.
Indexed as
Identifiers
3046367PMC1880758W2175508239What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.