Evidence map›Paper›PMID 30463560›Full record

ArticleRespiratory research2018

Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children.

Toby C Lewis, Ediri E Metitiri, Graciela B Mentz, Xiaodan Ren, Ashley R Carpenter, Adam M Goldsmith, Kyra E Wicklund, Breanna N Eder, Adam T Comstock, Jeannette M Ricci and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Review
  3. Review
  4. Cluster analysis of nasal cytokines during rhinovirus infection identifies different immunophenotypes in both children and adults with allergic asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Article
  5. Article
  6. Oxidative Stress-Related Mechanisms in SARS-CoV-2 Infections.Oxidative medicine and cellular longevity · 2022
    Review
  7. Nasal interferon responses to community rhinovirus infections are similar in controls and children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021
    Observational
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Toby C LewisDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Ediri E MetitiriDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Graciela B MentzHealth Behavior/Health Education, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Xiaodan RenEnvironmental Health Sciences, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Ashley R CarpenterDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Adam M GoldsmithDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Kyra E WicklundDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Breanna N EderDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Adam T ComstockDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Jeannette M RicciDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Sean R BrennanDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Ginger L WashingtonDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Kendall B OwensDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA.
Bhramar MukherjeeDepartments of Biostatistics, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Thomas G RobinsEnvironmental Health Sciences, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Stuart A BattermanEnvironmental Health Sciences, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Marc B HershensonDepartments of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1150 W. Medical Center Dr., Building MSRB2, Room 3570B, Ann Arbor, MI, 48109-5688, USA. mhershen@umich.edu.
Community Action Against Asthma Steering Committee
University of Michigan–Ann Arbor · US

Funding

University of Michigan ERC-supplement (TRT)T42OH008455 · OH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEITZEL, RICHARD L · 2005 to 2025
$32.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Role of Diesel and Other Vehicular Exhaust in Exacerbation of Childhood AsthmaR01ES014677 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBINS, THOMAS G · 2007 to 2011
$4.0M
Early Life Rhinovirus Infection and Childhood AsthmaR01AI120526 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERSHENSON, MARC B. · 2016 to 2024
$3.9M
Rhinovirus and Airway Epithelial Cell ResponsesR01HL081420 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERSHENSON, MARC B. · 2006 to 2014
$3.3M
Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic ChildrenR01ES016769 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEWIS, TOBY C · 2010 to 2014
$3.0M
Respiratory viral infection and microRNA in children with asthmaR21AI114220 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERSHENSON, MARC B., LEWIS, TOBY C · 2015 to 2016
$427k
NHLBI NIH HHS R01 HL081420NIAID NIH HHS R21 AI114220NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES014677NIEHS NIH HHS R01 ES016769NIH HHS AI114220NIOSH CDC HHS T42 OH008455
6 · The paper itself

Abstract

backgroundFew longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships.

methodsChildren underwent home collections of nasal lavage during scheduled surveillance periods and self-reported respiratory illnesses. We studied 53 children for one year, analyzing 392 surveillance samples and 203 samples from 85 respiratory illnesses. Generalized estimated equations were used to evaluate associations between nasal lavage biomarkers (7 mRNAs, 10 proteins), lung function and viral infection.

resultsAs anticipated, viral infection was associated with increased cytokines and reduced FVC and FEV

conclusionsIn asthmatic children, airflow obstruction is driven by specific pro-inflammatory cytokines. In the absence of viral infection, higher cytokine levels are associated with decreasing lung function. However, with infection, there is a reversal in this relationship, with cytokine abundance associated with reduced lung function decline. While nasal samples may not reflect lower airway responses, these data suggest that some aspects of the inflammatory response may be protective against viral infection. This study may have ramifications for the treatment of viral-induced asthma exacerbations.

Indexed as

AsthmaBiomarkersChildChild, PreschoolCytokinesFemaleHumansLongitudinal StudiesLungMaleNasal LavageRespiratory Tract InfectionsVirus DiseasesBiomarkersCytokinesAsthmaChemokineChildrenCytokineFEV1FVCRhinovirusUrbanViral

Identifiers

PMID30463560
PMCPMC6249926
OpenAlexW2901581579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.