Evidence map›Paper›PMID 30463531›Full record

ArticleBMC nephrology2018

Renal dysfunction among adult HIV/AIDS patients on antiretroviral therapy at a tertiary facility in Ghana.

Dorcas Obiri-Yeboah, Yaw Asante Awuku, Wonderful Alofa, Alice Charwudzi, Ebenezer Aniakwa-Bonsu, Evans Obboh, Paul Nsiah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dorcas Obiri-YeboahDepartment of Microbiology and Immunology, School of Medical Sciences, CoHAS, University of Cape Coast, Private Mail bag, Cape Coast, Ghana. d.obiri-yeboah@uccsms.edu.gh.ORCID 0000-0003-4562-9294
Yaw Asante AwukuDepartment of Internal Medicine and Therapeutics, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
Wonderful AlofaDepartment of Medical Laboratory Technology, School of Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Alice CharwudziDepartment of Haematology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
Ebenezer Aniakwa-BonsuDepartment of Microbiology and Immunology, School of Medical Sciences, CoHAS, University of Cape Coast, Private Mail bag, Cape Coast, Ghana.
Evans ObbohDepartment of Microbiology and Immunology, School of Medical Sciences, CoHAS, University of Cape Coast, Private Mail bag, Cape Coast, Ghana.
Paul NsiahDepartment of Chemical Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
University of Cape Coast · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney diseases have emerged as significant cause of morbidity and mortality in HIV subject on antiretroviral therapy (ART). In Ghana, routine follow up of HIV positive clients is by estimation of serum creatinine and urea levels. Glomerular Filtration Rate (GFR) is not routinely calculated and proteinuria is not routinely checked. This study sought to investigate the kidney profiles of adult HIV/AIDS patients being managed on ART at the Cape Coast Teaching Hospital (CCTH), Ghana.

methodsA hospital-based analytical cross sectional study with a retrospective component was conducted using systematic sampling method to recruit HIV/AIDS who visited the ART clinic. A total of 440 participants of both sexes aged 18 years and above, confirmed as HIV/AIDS positive and on ART were involved in this study. Blood and urine samples were collected from all subjects and the levels of serum creatinine and urea and proteinuria were estimated and eGFR calculated using the Modification of Diet in Renal Disease (MDRD) equations. Data analyses were performed using Stata version 13 software (Stata Corp, Texas USA).

resultsThe mean age (years) of participants was 45.5 years (±11.6) with 288 (65.4%) being on Tenofovir based ART regimen. The mean eGFR was found to decrease from 112.4 ml/min/1.73 m at baseline, to 103.4 ml/min/1.73 m after 6 months on ART and to a mean of 99.4 ml/min/1.73 m at recruitment into this study. Factors which were found to be associated with having eGFR < 60 included age, gender and CD4 count though not statistically significant. Patients > 45 years had the highest odds with OR 2.0 (95% CI: 0.8-5.1), females had higher odds with OR 1.5 (95% CI: 0.5-5.2), and those with CD4 count > 350 had OR of 0.4 (95% CI 0.2-1.3). A total of 30.9% of the participants had proteinuria at recruitment. TDF based ART regimen had no statistically significant effect on serum creatinine and urea levels.

conclusionEstimated GFR decreased after 6 months among patients on ART despite normal serum creatinine and urea levels. This finding suggests that clients in care at HIV/ART clinics in Ghana may benefit from routine estimation of GFR and proteinuria.

Indexed as

Acquired Immunodeficiency SyndromeAdultAnti-Retroviral AgentsCohort StudiesCross-Sectional StudiesFemaleFollow-Up StudiesGhanaGlomerular Filtration RateHIV InfectionsHumansKidney DiseasesMaleMiddle AgedTertiary Care CentersAnti-Retroviral Agents

Identifiers

PMID30463531
PMCPMC6249759
OpenAlexW2901382119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.