ArticleBMC cancer2018
Radiomics score: a potential prognostic imaging feature for postoperative survival of solitary HCC patients.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.
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Who cites it
85 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prediction of PD-L1 expression in nonsmall cell lung cancer using artificial intelligence models based on radiomics: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Systematic review: radiomics for the diagnosis and prognosis of hepatocellular carcinoma.Alimentary pharmacology & therapeutics · 2021Pooled it
- Comparative analysis of radiomics and deep-learning algorithms for survival prediction in hepatocellular carcinoma.Scientific reports · 2024Trial
- Preoperative contrast-enhanced computed tomography-based radiomics model for overall survival prediction in hepatocellular carcinoma.World journal of gastroenterology · 2022Trial
- Comprehensive radiomics nomogram for predicting survival of patients with combined hepatocellular carcinoma and cholangiocarcinoma.World journal of gastroenterology · 2021Trial
- Development and Validation of a Coronary Computed Tomography Angiography-Based Radiomics-Integrated Model for Noninvasive Detection of Left Atrial Appendage Thrombus in Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- Three-dimensional multimodal imaging for predicting early recurrence of hepatocellular carcinoma after surgical resection.Journal of advanced research · 2026Article
- Enhancing cancer prognostics with group penalty models: a comparative study on radiomics feature selection in lung adenocarcinomas and meningiomas.Quantitative imaging in medicine and surgery · 2026Article
- Commentary on "Imaging-based surrogate classification for risk stratification of hepatocellular carcinoma with microvascular invasion to adjuvant hepatic arterial infusion chemotherapy: a multicenter retrospective study".International journal of surgery (London, England) · 2026Article
- CT-Based Radiomics for Non-Invasive Prediction of Ki-67 Expression in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2026Article
- A Noninvasive Predictive Model of Portal Hypertension in Patients with HCC Based on Clinical Features and Intra- and Peritumoral Pre-Fusion Radiomic Features.Journal of hepatocellular carcinoma · 2026Article
- Critical dialogue: Can AI-based imaging predict tumor biology? Infer metastasis, microvascular invasion, and growth patterns from pixels.Insights into imaging · 2025Article
- Radiomics-based machine-learning method to predict extrahepatic metastasis in hepatocellular carcinoma after hepatectomy: a multicenter study.Scientific reports · 2025Article
- Integrating Radiomics and Deep-Learning for Prognostic Evaluation in Nasopharyngeal Carcinoma.Medicina (Kaunas, Lithuania) · 2025Review
- CCL26 as a prognostic biomarker in hepatocellular carcinoma: integrating bioinformatics analysis, clinical validation, and radiomics score.Discover oncology · 2025Article
- Establishment of a predictive nomogram for breast cancer lympho-vascular invasion based on radiomics obtained from digital breast tomography and clinical imaging features.BMC medical imaging · 2025Article
- On the robustness of [18F]-FDG-PET radiomic features to variations in image acquisition and reconstruction settings: A phantom study.PloS one · 2025Article
- Predictive Radiomics-Based Model for Recurrence-Free Survival After Curative Resection in Patients with Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2025Article
- Radiomics-based multiple machine learning approaches for investigating medial wall invasion of the cavernous sinus in pituitary adenomas.Frontiers in oncology · 2025Article
- Establishing a Survival Time Prediction Model for Patients with Hepatocellular Carcinoma After TACE Based on CT Radiomics: A Multi-Center Study.Journal of hepatocellular carcinoma · 2025Article
25 more citing papers are in PubMed but not listed here.
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Abstract
backgroundRadiomics is an emerging field in oncological research. In this study, we aimed at developing a radiomics score (rad-score) to estimate postoperative recurrence and survival in patients with solitary hepatocellular carcinoma (HCC).
methodsA total of 319 solitary HCC patients (training cohort: n = 212; validation cohort: n = 107) were enrolled. Radiomics features were extracted from the artery phase of preoperatively acquired computed tomography (CT) in all patients. A rad-score was generated by using the least absolute shrinkage and selection operator (lasso) logistic model. Kaplan-Meier and Cox's hazard regression analyses were used to evaluate the prognostic significance of the rad-score. Final nomograms predicting recurrence and survival of solitary HCC patients were established based on the rad-score and clinicopathological factors. C-index and calibration statistics were used to assess the performance of nomograms.
resultsSix potential radiomics features were selected out of 110 texture features to formulate the rad-score. Low rad-score positively correlated with aggressive tumor phenotypes, like larger tumor size and vascular invasion. Meanwhile, low rad-score was significantly associated with increased recurrence and reduced survival. In addition, multivariate analysis identified the rad-score as an independent prognostic factor (recurrence: Hazard ratio (HR): 2.472, 95% confident interval (CI): 1.339-4.564, p = 0.004;survival: HR: 1.558, 95%CI: 1.022-2.375, p = 0.039). Notably, the nomogram integrating rad-score had a better prognostic performance as compared with traditional staging systems. These results were further confirmed in the validation cohort.
conclusionsThe preoperative CT image based rad-score was an independent prognostic factor for the postoperative outcome of solitary HCC patients. This score may be complementary to the current staging system and help to stratify individualized treatments for solitary HCC patients.
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