ArticleBMC cardiovascular disorders2018
Association of sleep problems with neuroendocrine hormones and coagulation factors in patients with acute myocardial infarction.
Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01781247 (MI-SPRINT), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MI-SPRINT (Myocardial Infarction - Stress PRevention INTervention): A Randomized Controlled Minimal Early Behavioral Intervention Trial to Reduce the Development of Posttraumatic Stress Caused by Acute Myocardial Infarction
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Obstructive Sleep Apnea and Hypercoagulability: Combining Observational and Mendelian Randomization Analyses to Explore Causal Relationships.Nature and science of sleep · 2026Article
- Exploring the Interaction Between Sleep Patterns, Cardiac Autonomic Function, and Traditional Cardiovascular Risk Factors Following Acute Myocardial Infarction.Clinical cardiology · 2025Article
- Sleep disorders in the acute phase of coronavirus disease 2019: an overview and risk factor study.Annals of general psychiatry · 2023Article
- Review
- Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields.Environmental health : a global access science source · 2022Article
- B serum proteome profiles revealed dysregulated proteins and mechanisms associated with insomnia patients: A preliminary study.Frontiers in integrative neuroscience · 2022Article
- A time-series prediction model of acute myocardial infarction in northern of Iran: the risk of climate change and religious mourning.BMC cardiovascular disorders · 2021Article
- Prevalence of Common Disease Conditions in a Large Cohort of Individuals With Down Syndrome in the United States.Journal of patient-centered research and reviews · 2021Article
- Proteomic Profiling Reveals the Molecular Changes of Insomnia Patients.BioMed research international · 2021Article
- Association of sleep quality with telomere length, a marker of cellular aging: A retrospective cohort study of older adults in the United States.Sleep health · 2020Article
- Obstructive sleep apnea, intermittent hypoxemia and prothrombotic biomarkers.Sleep science (Sao Paulo, Brazil)Article
- The Association of Sleep Quality With Anorexia in Patients With Heart Failure: Do Anxiety and Depressive Symptoms Mediate This Association.The Journal of cardiovascular nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive sleep apnea (OSA) and insomnia are frequent sleep problems that are associated with poor prognosis in patients with coronary heart disease. The mechanisms linking poor sleep with an increased cardiovascular risk are incompletely understood. We examined whether a high risk of OSA as well as insomnia symptoms are associated with neuroendocrine hormones and coagulation factors in patients admitted with acute myocardial infarction.
methodsWe assessed 190 patients (mean age 60 years, 83% men) in terms of OSA risk (STOP screening tool for the assessment of high vs. low OSA risk) and severity of insomnia symptoms (Jenkins Sleep Scale for the assessment of subjective sleep difficulties) within 48 h of an acute coronary intervention. Circulating concentrations of epinephrine, norepinephrine, cortisol, fibrinogen, D-dimer, and von Willebrand factor were measured the next morning. The association of OSA risk and insomnia symptoms with neuroendocrine hormones and coagulation factors was computed using multivariate models adjusting for demographic factors, health behaviors, somatic and psychiatric comorbidities, cardiac disease-related variables, and OSA risk in the model for insomnia symptoms, respectively, for insomnia symptoms in the model for OSA risk.
resultsHigh OSA risk was identified in 41% of patients and clinically relevant insomnia symptoms were reported by 27% of patients. Compared to those with low OSA risk, patients with high OSA risk had lower levels of epinephrine (p = 0.015), norepinephrine (p = 0.049) and cortisol (p = 0.001). More severe insomnia symptoms were associated with higher levels of fibrinogen (p = 0.037), driven by difficulties initiating sleep, and with lower levels of norepinephrine (p = 0.024), driven by difficulties maintaining sleep.
conclusionsIn patients with acute myocardial infarction, sleep problems are associated with neuroendocrine hormones and coagulation activity. The pattern of these relationships is not uniform for patients with a high risk of OSA and those with insomnia symptoms, and whether they contribute to adverse cardiovascular outcomes needs to be established.
trial registrationClinicalTrials.gov NCT01781247 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.