Evidence map›Paper›PMID 30463495›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2019

The Absence of TLR4 Prevents Fetal Brain Injury in the Setting of Intrauterine Inflammation.

Natalia M Tulina, Amy G Brown, Guillermo O Barila, Michal A Elovitz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Natalia M Tulina1 Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Amy G Brown1 Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Guillermo O Barila1 Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michal A Elovitz1 Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · US

Funding

The role of TLR signaling in fetal brain injury from prenatal inflammationR01HD076032 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI ELOVITZ, MICHAL AVIVA · 2014 to 2018
$1.8M
NICHD NIH HHS R01 HD076032
6 · The paper itself

Abstract

backgroundExposure to intrauterine inflammation during pregnancy is linked to brain injury and neurobehavioral disorders in affected children. Innate immunity, specifically Toll-like receptor (TLR) signaling pathways are present throughout the reproductive tract as well as in the placenta, fetal membranes, and fetus. The TLR pathways are mechanistically involved in host responses to foreign pathogens and may lead to brain injury associated with prenatal inflammation.

objectiveWe aimed to determine whether the activation of the TLR4 signaling pathway, in the mother and fetus, is critical to fetal brain injury in the setting of intrauterine inflammation.

methodsA mini-laparotomy was performed on time pregnant C57B6 mice and 2 knockout mouse strains lacking the function of the

resultsUsing an established mouse model of intrauterine inflammation, we demonstrate that the abrogation of TLR4 signaling eliminates the cytokine response in mother and fetus and prevents brain injury associated with increased expression of transcriptional effectors of the NOTCH signaling pathway,

conclusionsThese data show that the activation of the TLR4 signaling pathway is necessary for the development of fetal brain injury in response to intrauterine inflammation.

Indexed as

Amniotic FluidAnimalsAnimals, NewbornBrain InjuriesFemaleInflammationLipopolysaccharidesMiceMice, KnockoutMyeloid Differentiation Factor 88PlacentaPregnancySignal TransductionToll-Like Receptor 4UterusLipopolysaccharidesMyd88 protein, mouseMyeloid Differentiation Factor 88Tlr4 protein, mouseToll-Like Receptor 4brain injuryintrauterine inflammationNOTCH signalingpregnancyTLR4 signaling

Identifiers

PMID30463495
PMCPMC6974595
OpenAlexW2901494435

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.