Evidence map›Paper›PMID 30463418›Full record

ArticleJournal of cutaneous medicine and surgery

Vaccination Guidelines for Patients With Immune-Mediated Disorders on Immunosuppressive Therapies.

Kim A Papp, Boulos Haraoui, Deepali Kumar, John K Marshall, Robert Bissonnette, Alain Bitton, Brian Bressler, Melinda Gooderham, Vincent Ho, Shahin Jamal and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cutaneous medicine and surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 8 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 8 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Guideline
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  3. Pooled it
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  6. Pooled it
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  9. Review
  10. Article
  11. Article
  12. Contemporary management of sarcoidosis.Frontiers in medicine · 2026
    Review
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  14. Review
  15. Article
  16. Article
  17. Article
  18. Treatment of Behçet Uveitis in Türkiye.Turkish journal of ophthalmology · 2024
    Article
  19. Review
  20. Hypogammaglobulinemia, late-onset neutropenia, and infections following rituximab.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 1 country.

Kim A Papp1 K Papp Clinical Research, Waterloo, ON, Canada.
Boulos Haraoui3 Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Deepali Kumar4 University Health Network, Toronto, ON, Canada.
John K Marshall6 Department of Medicine and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
Robert Bissonnette7 Innovaderm Research, Inc, Montreal, QC, Canada.ORCID https://orcid.org/0000-0001-5927-6587
Alain Bitton8 McGill University Health Centre, Montreal, QC, Canada.
Brian Bressler9 Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Melinda Gooderham2 Probity Medical Research, Waterloo, ON, Canada.
Vincent Ho9 Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Shahin Jamal12 Vancouver Coastal Health, Vancouver, BC, Canada.
Janet E Pope13 Faculty of Medicine, University of Western Ontario, London, ON, Canada.
A Hillary Steinhart5 Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Donald C Vinh8 McGill University Health Centre, Montreal, QC, Canada.
John Wade9 Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
University of British Columbia · CAMcGill University Health Centre · CACentre Hospitalier de l’Université de Montréal · CAInnovaderm (Canada) · CAMount Sinai Hospital · CAPopulation Health Research Institute · CAProbity Medical Research · CAQueen's University · CAUniversity Health Network · CAVancouver Coastal Health · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background: Patients with immune-mediated diseases on immunosuppressive therapies have more infectious episodes than healthy individuals, yet vaccination practices by physicians for this patient population remain suboptimal.

objectives: To evaluate the safety and efficacy of vaccines in individuals exposed to immunosuppressive therapies and provide evidence-based clinical practice recommendations.

methods: A literature search for vaccination safety and efficacy in patients on immunosuppressive therapies (2009-2017) was conducted. Results were assessed using the Grading of Recommendation, Assessment, Development, and Evaluation system.

results: Several immunosuppressive therapies attenuate vaccine response. Thus, vaccines should be administered before treatment whenever feasible. Inactivated vaccines can be administered without treatment discontinuation. Similarly, evidence suggests that the live zoster vaccine is safe and effective while on select immunosuppressive therapy, although use of the subunit vaccine is preferred. Caution regarding other live vaccines is warranted. Drug pharmacokinetics, duration of vaccine-induced viremia, and immune response kinetics should be considered to determine appropriate timing of vaccination and treatment (re)initiation. Infants exposed to immunosuppressive therapies through breastmilk can usually be immunized according to local guidelines. Intrauterine exposure to immunosuppressive agents is not a contraindication for inactivated vaccines. Live attenuated vaccines scheduled for infants and children ⩾12 months of age, including measles, mumps, rubella, and varicella, can be safely administered as sufficient time has elapsed for drug clearance.

conclusions: Immunosuppressive agents may attenuate vaccine responses, but protective benefit is generally maintained. While these recommendations are evidence based, they do not replace clinical judgment, and decisions regarding vaccination must carefully assess the risks, benefits, and circumstances of individual patients.

Indexed as

Immunocompromised HostPractice Guidelines as TopicVaccinationHumansImmune System DiseasesImmunosuppressive AgentsImmunosuppressive Agentsimmune-mediated diseaseimmunosuppressionvaccination

Identifiers

PMID30463418
PMCPMC6330697
OpenAlexW2900533123

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.