Evidence map›Paper›PMID 30463380›Full record

ArticleCancers2018

Mutational Evolution in Relapsed Diffuse Large B-Cell Lymphoma.

Marcel Nijland, Annika Seitz, Martijn Terpstra, Gustaaf W van Imhoff, Philip M Kluin, Tom van Meerten, Çiğdem Atayar, Léon C van Kempen, Arjan Diepstra, Klaas Kok and 1 more

Abstract read
In one paragraph

Article in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marcel NijlandDepartment of Hematology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. m.nijland@umcg.nl.ORCID 0000-0002-2740-2873
Annika SeitzDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. a.seitz@umcg.nl.
Martijn TerpstraDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. m.m.terpstra.cluster@gmail.com.
Gustaaf W van ImhoffDepartment of Hematology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. g.w.van.imhoff@umcg.nl.
Philip M KluinDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. p.m.kluin@umcg.nl.
Tom van MeertenDepartment of Hematology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. t.van.meerten@umcg.nl.
Çiğdem AtayarDepartment of Pathology, Treant Caregroup, Bethesda Hospital, 7909 AA Hoogenveen, The Netherlands. c.atayar@treant.nl.ORCID 0000-0001-7569-5108
Léon C van KempenDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. l.van.kempen@umcg.nl.ORCID 0000-0003-0646-0705
Arjan DiepstraDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. a.diepstra@umcg.nl.ORCID 0000-0001-9239-1050
Klaas KokDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. k.kok@umcg.nl.
Anke van den BergDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. a.van.den.berg01@umcg.nl.ORCID 0000-0002-8894-2638

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current genomic models in diffuse large B-cell lymphoma (DLBCL) are based on single tumor biopsies, which might underestimate heterogeneity. Data on mutational evolution largely remains unknown. An exploratory study using whole exome sequencing on paired (primary and relapse) formalin fixed paraffin embedded DLBCL biopsies (

Indexed as

diffuse large B-cell lymphomaevolutionfresh frozen paraffin embeddedheterogeneitymutationsrelapse

Identifiers

PMID30463380
PMCPMC6265691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.