Evidence map›Paper›PMID 30463374›Full record

ArticleNon-coding RNA2018

Long Non-Coding RNA Modulation of VEGF-A during Hypoxia.

Tiina Nieminen, Tristan A Scott, Feng-Mao Lin, Zhen Chen, Seppo Yla-Herttuala, Kevin V Morris

Abstract read
In one paragraph

Article in Non-coding RNA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Genomic Landscapes of Noncoding RNAs RegulatingMolecular and cellular biology · 2021
    Article
  9. The roles and mechanisms of hypoxia in liver fibrosis.Journal of translational medicine · 2021
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tiina NieminenThe Center for Gene Therapy, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. timaniem@gmail.com.
Tristan A ScottThe Center for Gene Therapy, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. trscott@coh.org.
Feng-Mao LinDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. flin@coh.org.
Zhen ChenDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. zhenchen@coh.org.ORCID 0000-0002-3291-1090
Seppo Yla-HerttualaDepartment of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. seppo.ylaherttuala@uef.fi.ORCID 0000-0001-7593-2708
Kevin V MorrisThe Center for Gene Therapy, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. kmorris@coh.org.ORCID 0000-0002-0157-0553

Funding

Transcriptional control, targeted modification, and excision of HIV in the brainR01MH113407 · NIMH · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BURNETT, JOHN CORY · 2017 to 2021
$3.0M
Targeted inhibition of HIV-1 latencyR01AI111139 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI MORRIS, KEVIN V · 2014 to 2018
$2.7M
Activating cystic fibrosis transmembrane conductance regulator: the therapeutic potential of RNA directed gene activationR01DK104681 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI MORRIS, KEVIN V · 2015 to 2019
$1.9M
National Institutes of Health 113407-01National Institutes of Health AI099783-01National Institutes of Health AI111139-01NIAID NIH HHS R01 AI111139NIDDK NIH HHS R01 DK104681NIMH NIH HHS R01 MH113407
6 · The paper itself

Abstract

The role and function of long non-coding RNAs (lncRNAs) in modulating gene expression is becoming apparent. Vascular endothelial growth factor A (VEGF-A) is a key regulator of blood vessel formation and maintenance making it a promising therapeutic target for activation in ischemic diseases. In this study, we uncover a functional role for two antisense VEGF-A lncRNAs,

Indexed as

antisense RNAlong non-coding RNA (lncRNA)transcriptional activationvascular endothelial growth factor A (VEGF-A)

Identifiers

PMID30463374
PMCPMC6315885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.