Evidence map›Paper›PMID 30463312›Full record

ArticleInternational journal of molecular sciences2018

Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk Profile.

Cristina Galarregui, María Ángeles Zulet, Irene Cantero, Bertha Araceli Marín-Alejandre, José Ignacio Monreal, Mariana Elorz, Alberto Benito-Boillos, José Ignacio Herrero, Josep Antoni Tur, Itziar Abete and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cristina GalarreguiDepartment of Nutrition, Food Science and Physiology and Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. cgalarregui@alumni.unav.es.
María Ángeles ZuletDepartment of Nutrition, Food Science and Physiology and Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. mazulet@unav.es.
Irene CanteroDepartment of Nutrition, Food Science and Physiology and Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. icantero.1@alumni.unav.es.
Bertha Araceli Marín-AlejandreDepartment of Nutrition, Food Science and Physiology and Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. bmarin.1@alumni.unav.es.
José Ignacio MonrealNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. jimonreal@unav.es.
Mariana ElorzNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. marelorz@unav.es.
Alberto Benito-BoillosNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. albenitob@unav.es.
José Ignacio HerreroNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. iherrero@unav.es.
Josep Antoni TurBiomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. pep.tur@uib.es.ORCID 0000-0002-6940-0761
Itziar AbeteDepartment of Nutrition, Food Science and Physiology and Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. iabetego@unav.es.ORCID 0000-0002-6475-5387
José Alfredo MartínezDepartment of Nutrition, Food Science and Physiology and Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. jalfmtz@unav.es.ORCID 0000-0001-5218-6941

Funding

Departamento de Educación, Gobierno de Navarra 61/2015Fundació la Marató de TV3 201630.10
6 · The paper itself

Abstract

backgroundDietary total antioxidant capacity (TAC), glycemic index (GI), and glycemic load (GL) are accepted indicators of diet quality, which have an effect on diet⁻disease relationships. The aim of this study was to evaluate potential associations of dietary TAC, GI, and GL with variables related to nutritive status and insulin resistance (IR) risk in cardiometabolic subjects.

methodsA total of 112 overweight or obese adults (age: 50.8 ± 9 years old) were included in the trial. Dietary intake was assessed by a validated 137-item food frequency questionnaire (FFQ), which was also used to calculate the dietary TAC, GI, and GL. Anthropometrics, blood pressure, body composition by dual-energy X-ray absorptiometry (DXA), glycemic and lipid profiles, C-reactive protein (CRP), as well as fatty liver quantification by magnetic resonance imaging (MRI) were assessed.

resultsSubjects with higher values of TAC had significantly lower circulating insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR). Participants with higher values of HOMA-IR showed significantly higher GI and GL. Correlation analyses showed relevant inverse associations of GI and GL with TAC. A regression model evidenced a relationship of HOMA-IR with TAC, GI, and GL.

conclusionThis data reinforces the concept that dietary TAC, GI, and GL are potential markers of diet quality, which have an impact on the susceptible population with a cardiometabolic risk profile.

Indexed as

DietGlycemic IndexGlycemic LoadInsulin ResistanceAntioxidantsCardiovascular DiseasesFemaleHumansLinear ModelsMaleMetabolic DiseasesMiddle AgedRisk FactorsAntioxidantsantioxidantsdiabetesdietglucoseprecision nutrition

Identifiers

PMID30463312
PMCPMC6275010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.