ArticleInternational journal of molecular sciences2018
Beneficial Effects of Deoxyshikonin on Delayed Wound Healing in Diabetic Mice.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Textilinin-1, a Snake Venom-Derived Kunitz-Type Protease Inhibitor, Accelerates Wound Healing Through Anti-Inflammatory, Antibacterial, and Pro-Regenerative Activities.Pharmaceutics · 2026Article
- Integrating habitat suitability, phytochemical quality, and landscape stability to identify conservation priorities forFrontiers in plant science · 2026Article
- Deoxyshikonin Inhibits Influenza A Virus Infection at an Early Stage.International journal of molecular sciences · 2025Article
- Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation.Stem cell research & therapy · 2025Article
- Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice.Nature communications · 2025Article
- X-Paste improves wound healing in diabetesWorld journal of diabetes · 2024Article
- Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing.Antioxidants (Basel, Switzerland) · 2023Review
- In vitro wound healing potential of cyclohexane extract of Onosma dichroantha Boiss. based on bioassay-guided fractionation.Scientific reports · 2023Article
- Research on the wound healing effect of Shengji Huayu Formula ethanol extract-derived fractions in streptozotocin-induced diabetic ulcer rats.BMC complementary medicine and therapies · 2023Article
- Identification of Phytogenic Compounds with Antioxidant Action That Protect Porcine Intestinal Epithelial Cells from Hydrogen Peroxide Induced Oxidative Damage.Antioxidants (Basel, Switzerland) · 2022Article
- Discovery of natural products capable of inducing porcine host defense peptide gene expression using cell-based high throughput screening.Journal of animal science and biotechnology · 2021Article
- Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing.Frontiers in bioengineering and biotechnology · 2021Review
- Deoxyshikonin-Induced Gene Expression Profile in Porcine Epithelial Cells.Frontiers in veterinary science · 2021Article
- Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway.Molecules (Basel, Switzerland) · 2019Article
- Article
- New Innovations in Wound Healing and Repair.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Shiunko ointment is composed of five ingredients including Lithospermi Radix (LR), Angelicae Gigantis Radix, sesame seed oil, beeswax, and swine oil. It is externally applied as a treatment for a wide range of skin conditions such as eczema, psoriasis, hair loss, burns, topical wounds, and atopic dermatitis. Deoxyshikonin is the major angiogenic compound extracted from LR. In this study, we investigated the efficacy of LR extract and deoxyshikonin on impaired wound healing in streptozotocin (STZ)-induced diabetic mice. Treatment with LR extract elevated tube formation in human umbilical vein endothelial cells (HUVECs) and exerted antioxidant activity. An open skin wound was produced on the backs of diabetic mice and was then topically treated with deoxyshikonin or vehicle. In addition, deoxyshikonin promoted tube formation in high glucose conditions exposed to HUVECs, and which may be regulated by increased VEGFR2 expression and phosphorylation of Akt and p38. Our results demonstrate that deoxyshikonin application promoted wound repair in STZ-induced diabetic mice. Collectively, these data suggest that deoxyshikonin is an active ingredient of LR, thereby contributing to wound healing in patients with diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.