ReviewPharmaceutics2018
Diatoms Green Nanotechnology for Biosilica-Based Drug Delivery Systems.
Review in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 106 citations in OpenAlex.
- In Vivo Fate of Diatom-Based Nanocarriers: Advances, Challenges, and Future Perspectives.International journal of molecular sciences · 2026Review
- A New Algal Friendly Extract fromMarine drugs · 2025Article
- Harnessing Microalgae as Sustainable Cell Factories for Polyamine-Based Nanosilica for Biomedical Applications.Molecules (Basel, Switzerland) · 2025Review
- Biohybrid Nanosystem Fabricated with Marine DiatomACS biomaterials science & engineering · 2025Article
- Diatoms: harnessing nature's microscopic marvels for biosensing and multifaceted applications.Biophysical reviews · 2025Review
- A Descriptive Review on the Potential Use of Diatom Biosilica as a Powerful Functional Biomaterial: A Natural Drug Delivery System.Pharmaceutics · 2024Review
- The draft genome of Nitzschia closterium f. minutissima and transcriptome analysis reveals novel insights into diatom biosilicification.BMC genomics · 2024Article
- Diatom-Inspired Structural Adaptation According to Mode Shapes: A Study on 3D Structures and Software Tools.Biomimetics (Basel, Switzerland) · 2024Article
- Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review.International journal of molecular sciences · 2024Review
- Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds' Delivery: State-of-the Art and Challenges.Materials (Basel, Switzerland) · 2023Review
- Recent Progress in Diatom Biosilica: A Natural Nanoporous Silica Material as Sustained Release Carrier.Pharmaceutics · 2023Review
- Drug Delivery through Epidermal Tissue Cells by Functionalized Biosilica from Diatom Microalgae.Marine drugs · 2023Article
- Diatom-Based Nanomedicine for Colorectal Cancer Treatment: New Approaches for Old Challenges.Marine drugs · 2023Review
- Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles.Marine drugs · 2022Review
- Comparison of Biogenic Amorphous Silicas Found in Common Horsetail and Oat Husk With Synthetic Amorphous Silicas.Frontiers in public health · 2022Review
- Diatom microalgae as smart nanocontainers for biosensing wastewater pollutants: recent trends and innovations.Bioengineered · 2021Review
- Study on the Hemostasis Characteristics of Biomaterial Frustules Obtained from DiatomMaterials (Basel, Switzerland) · 2021Article
- Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential.International journal of molecular sciences · 2021Article
- Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications.Biosensors · 2021Review
- Porous Silicon Optical Devices: Recent Advances in Biosensing Applications.Sensors (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diatom microalgae are the most outstanding natural source of porous silica. The diatom cell is enclosed in a three-dimensional (3-D) ordered nanopatterned silica cell wall, called frustule. The unique properties of the diatom frustule, including high specific surface area, thermal stability, biocompatibility, and tailorable surface chemistry, make diatoms really promising for biomedical applications. Moreover, they are easy to cultivate in an artificial environment and there is a large availability of diatom frustules as fossil material (diatomite) in several areas of the world. For all these reasons, diatoms are an intriguing alternative to synthetic materials for the development of low-cost drug delivery systems. This review article focuses on the possible use of diatom-derived silica as drug carrier systems. The functionalization strategies of diatom micro/nanoparticles for improving their biophysical properties, such as cellular internalization and drug loading/release kinetics, are described. In addition, the realization of hybrid diatom-based devices with advanced properties for theranostics and targeted or augmented drug delivery applications is also discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.