Evidence map›Paper›PMID 30463256›Full record

ArticleInternational journal of molecular sciences2018

Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1β in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.

Takako Takemiya, Marumi Kawakami, Chisen Takeuchi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Takako TakemiyaMedical Research Institute, Tokyo Women's Medical University, Tokyo 162-8666, Japan. takemiya.takako@twmu.ac.jp.ORCID 0000-0003-0877-5698
Marumi KawakamiMedical Research Institute, Tokyo Women's Medical University, Tokyo 162-8666, Japan. kawakami.marumi@twmu.ac.jp.
Chisen TakeuchiDepartment of Neurology, Tokyo Metropolitan Kita Medical and Rehabilitation Center for the Disabled, Tokyo 114-0033, Japan. chisentakeuchi@gmail.com.
Tokyo Women's Medical University · JPTokyo-Kita Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsomal prostaglandin E synthetase-1 (mPGES-1) is an inducible terminal enzyme for the production of prostaglandin E₂ (PGE₂). In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, mPGES-1 is induced in vascular endothelial cells (VECs) around inflammatory foci and facilitates inflammation, demyelination, and paralysis. Therefore, we investigated the role of CD31-positive VECs in mPGES-1-mediated EAE aggravation using immunohistochemical analysis and imaging of wild-type (wt) and

Indexed as

Disease ProgressionUp-RegulationAnimalsDemyelinating DiseasesDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalEndothelial CellsFemaleInterleukin-1betaMice, Inbred C57BLMicrosomesModels, BiologicalParalysisPlatelet Endothelial Cell Adhesion Molecule-1Prostaglandin-E SynthasesReceptors, Interleukin-1Interleukin-1betaPlatelet Endothelial Cell Adhesion Molecule-1Prostaglandin-E SynthasesPtges protein, mouseReceptors, Interleukin-1Receptors, Prostaglandin Eexperimental autoimmune encephalomyelitisinterleukin-1βmicrosomal prostaglandin E synthetase-1multiple sclerosisprostaglandin E2vascular endothelial cells

Identifiers

PMID30463256
PMCPMC6274996
OpenAlexW2900848660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.