Evidence map›Paper›PMID 30463036›Full record

ArticleVirology2019

The role of side tail fibers during the infection cycle of phage lambda.

Jingwen Guan, David Ibarra, Lanying Zeng

Abstract read
In one paragraph

Article in Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jingwen GuanMolecular and Environmental Plant Science, Texas A&M University, College Station, TX 77843, USA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA; Center for Phage Technology, Texas A&M University, College Station, TX 77843, USA.
David IbarraDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.
Lanying ZengMolecular and Environmental Plant Science, Texas A&M University, College Station, TX 77843, USA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA; Center for Phage Technology, Texas A&M University, College Station, TX 77843, USA. Electronic address: lzeng@tamu.edu.
Texas A&M University · US

Funding

Integration of Diverse Inputs Determines Developmental OutcomesR01GM107597 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI BALAZSI, GABOR, ZENG, LANYING · 2015 to 2018
$1.7M
NIGMS NIH HHS R01 GM107597
6 · The paper itself

Abstract

Bacteriophage λ has served as an important model for molecular biology and different cellular processes over the past few decades. In 1992, the phage strain used in most laboratories around the world, thought of as λ wild type, was discovered to carry a mutation in the stf gene which encodes four side tail fibers. Up to now, the role of the side tail fibers during the infection cycle, especially at the single-cell level, remains largely unknown. Here we utilized fluorescent reporter systems to characterize the effect of the side tail fibers on phage infection. We found that the side tail fibers interfere with phage DNA ejection process, most likely through the binding with their receptors, OmpC, leading to a more frequent failed infection. However, the side tail fibers do not seem to affect the lysis-lysogeny decision-making or lysis time.

Indexed as

Bacterial Outer Membrane ProteinsBacteriophage lambdaEscherichia coliMicroscopy, FluorescenceMutationPorinsReceptors, VirusSingle-Cell AnalysisViral Tail ProteinsVirus AttachmentVirus InternalizationBacterial Outer Membrane ProteinsOmpC proteinPorinsReceptors, VirusViral Tail ProteinsBacteriophage λCellular decision-makingFailed infectionPhage DNA ejectionSide tail fiber

Identifiers

PMID30463036
PMCPMC6312755
OpenAlexW2900647221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.