Evidence map›Paper›PMID 30463020›Full record

ArticleCell reports2018

Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance.

Rachel M Woodhouse, Gabriele Buchmann, Matthew Hoe, Dylan J Harney, Jason K K Low, Mark Larance, Peter R Boag, Alyson Ashe

Open access · goldAbstract read
PubMed Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 70 citations in OpenAlex.

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  7. Intraspecific variation in the duration of epigenetic inheritance.bioRxiv : the preprint server for biology · 2025
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  20. Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rachel M WoodhouseThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Gabriele BuchmannThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Matthew HoeThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Dylan J HarneyThe University of Sydney, Charles Perkins Centre, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Jason K K LowThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Mark LaranceThe University of Sydney, Charles Perkins Centre, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Peter R BoagMonash University, Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Clayton, VIC 3800, Australia.
Alyson AsheThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia; The University of Wollongong, School of Biological Sciences and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia. Electronic address: alyson.ashe@sydney.edu.au.
University of Sydney · AUIllawarra Health and Medical Research Institute · AUMonash University · AU

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Some epigenetic modifications are inherited from one generation to the next, providing a potential mechanism for the inheritance of environmentally acquired traits. Transgenerational inheritance of RNAi phenotypes in Caenorhabditis elegans provides an excellent model to study this phenomenon, and although studies have implicated both chromatin modifications and small RNA pathways in heritable silencing, their relative contributions remain unclear. Here, we demonstrate that the putative histone methyltransferases SET-25 and SET-32 are required for establishment of a transgenerational silencing signal but not for long-term maintenance of this signal between subsequent generations, suggesting that transgenerational epigenetic inheritance is a multi-step process with distinct genetic requirements for establishment and maintenance of heritable silencing. Furthermore, small RNA sequencing reveals that the abundance of secondary siRNAs (thought to be the effector molecules of heritable silencing) does not correlate with silencing phenotypes. Together, our results suggest that the current mechanistic models of epigenetic inheritance are incomplete.

Indexed as

Epigenesis, GeneticAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChromatinGene SilencingGerm CellsHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesInheritance PatternsLongevityLysineMaleMethylationModels, GeneticCaenorhabditis elegans ProteinsChromatinHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesLysineRNARNA, Small InterferingSET-25 protein, C elegansset-32 protein, C eleganschromatinepigeneticsinheritanceRNAismall RNAtransgenerational

Identifiers

PMID30463020
OpenAlexW2901793276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.