Evidence map›Paper›PMID 30462997›Full record

ReviewImmunity2018

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules.

Rick M Maizels, Hermelijn H Smits, Henry J McSorley

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Proteasomal-dependent endothelial P2YPurinergic signalling · 2026
    Article

192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rick M MaizelsWellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK. Electronic address: rick.maizels@glasgow.ac.uk.
Hermelijn H SmitsLeiden University Medical Center, Leiden, the Netherlands. Electronic address: h.h.smits@lumc.nl.
Henry J McSorleyCentre for Inflammation Research, University of Edinburgh, Edinburgh, UK. Electronic address: henry.mcsorley@ed.ac.uk.

Funding

Wellcome Trust 106122
6 · The paper itself

Abstract

Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.

Indexed as

Host-Parasite InteractionsImmunomodulationAdaptive ImmunityAnimalsBiological EvolutionDendritic CellsHelminthiasisHelminthsHumansImmunity, InnateMacrophages

Identifiers

PMID30462997
PMCPMC6269126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.