Evidence map›Paper›PMID 30462991›Full record

ArticleImmunity2018

Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed.

Katrina Lichauco, Mark S Lee, Michael S Kuhns

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katrina LichaucoDepartment of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Mark S LeeDepartment of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Michael S KuhnsDepartment of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ 85724, USA; The BIO-5 Institute, The University of Arizona College of Medicine, Tucson, AZ 85724, USA; The Arizona Center on Aging, The University of Arizona College of Medicine, Tucson, AZ 85724, USA; The University of Arizona Cancer Center, The University of Arizona College of Medicine, Tucson, AZ 85724, USA. Electronic address: mkuhns@email.arizona.edu.
University of Arizona · US

Funding

Probing the mechanistic basis for T cell fate decisions (R01)R01AI101053 · NIAID · UNIVERSITY OF ARIZONA · PI KUHNS, MICHAEL S · 2012 to 2021
$3.5M
NIAID NIH HHS R01 AI101053
6 · The paper itself

Abstract

How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.

Indexed as

Receptor-CD3 Complex, Antigen, T-CellReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaSignal TransductionT-LymphocytesReceptor-CD3 Complex, Antigen, T-CellReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID30462991
OpenAlexW2901381662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.