ArticleJournal of the American Geriatrics Society2018
Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia.
Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Lifetime Exposure to Endogenous Estradiol and Markers of Dementia Risk: Associations with Later Life Cognitive, Behavioral, and Functional Complaints.Diagnostics (Basel, Switzerland) · 2026Article
- Persistent Functional Impairment as an Early Indicator of Alzheimer Disease Pathology and Progression.Journal of the American Geriatrics Society · 2026Article
- Persistent functional impairment as an early indicator of cognitive decline and dementia in cognitively normal older adults.Journal of Alzheimer's disease : JAD · 2026Article
- Linking traditional and technological activities of daily living: Building modern, adaptable measures of daily functioning.Journal of the International Neuropsychological Society : JINS · 2025Article
- Association of Performance on the Financial Capacity Instrument-Short Form With Brain Amyloid Load and Cortical Thickness in Older Adults.Neurology. Clinical practice · 2022Article
- Medical and nursing home costs: From cognitively unimpaired through dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD): A Report of an International Research Collaboration Network.Journal of Alzheimer's disease : JAD · 2022Review
- Gait Speed and Instrumental Activities of Daily Living in Older Adults After Hospitalization: A Longitudinal Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- NIA-AA Alzheimer's Disease Framework: Clinical Characterization of Stages.Annals of neurology · 2021Article
- The Association Between Functional Assessment and Structural Brain Biomarkers in an Ethnically Diverse Sample With Normal Cognition, Mild Cognitive Impairment, or Dementia.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Article
- Brain amyloid, cortical thickness, and changes in activities of daily living.Annals of clinical and translational neurology · 2020Article
- Association Between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging.Journal of Alzheimer's disease : JAD · 2020Article
- Optogenetic gamma stimulation rescues memory impairments in an Alzheimer's disease mouse model.Nature communications · 2019Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesTo examine the cross-sectional association between functional performance and Alzheimer's disease (AD) neuroimaging biomarkers in individuals without dementia (cognitively unimpaired (CU), and those with mild cognitive impairment (MCI)).
designCross-sectional.
settingOlmsted County, Minnesota.
participantsPopulation-based Mayo Clinic Study of Aging (MCSA) participants (aged ≥ 50, mean age 71.3 ± 10.2; 53.4% male; 28.3% apolipoprotein (APO)E ε4 allele carriers, 1,578 CU, 204 MCI) who underwent MEASUREMENTS: We defined an abnormal (high)
resultsParticipants with a CDR-SOB (functional) score greater than 0 were almost 4 times as likely to have N + (odds ratio (OR)=3.92, 95% confidence interval (CI)=1.77-8.67, adjusting for age, sex, education, global cognitive z-score, and APOE ε4 allele status; p<.001) and those with a FAQ score greater than 0 were 1.5 times as likely to have A + (OR=1.48, 95% CI=1.04-2.11, p=.03). Higher FAQ scores were associated with greater odds of A+N + and A-N + in CU participants.
conclusionThe findings of this cross-sectional study supplement limited available information that supports an association between functional performance and AD neuroimaging biomarkers very early in the dementia pathophysiology. The associations should be validated in longitudinal studies. J Am Geriatr Soc 66:2274-2281, 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.