Trial reportArchives of endocrinology and metabolism2018
Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial.
Trial report in Archives of endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Additional treatment strategies for hypothyroidism: a network meta-analysis.Endocrine connections · 2026Pooled it
- Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.Thyroid : official journal of the American Thyroid Association · 2021Guideline
- Variable intensity interval training improves cardiorespiratory fitness and quality of life across Hashimoto's stages and lowers TSH in subclinical patients: a 12-week supervised study.European journal of applied physiology · 2026Article
- A cross-sectional study on the lifestyle of patients with Hashimoto's thyroiditis.BMC endocrine disorders · 2026Article
- Review
- Lifestyle and Quality of Life of Women with Diagnosed Hypothyroidism in the Context of Metabolic Disorders.Metabolites · 2023Article
- Symptoms in Patients Being Treated for Hypothyroidism: New Data in a Continuing Controversy.Thyroid : official journal of the American Thyroid Association · 2023Article
- Which physical activity in patients affected by hypoparathyroidism? A review of the literature and practical recommendations.Journal of endocrinological investigation · 2022Review
- Brain Fog in Hypothyroidism: What Is It, How Is It Measured, and What Can Be Done About It.Thyroid : official journal of the American Thyroid Association · 2022Review
- Optimal Thyroid Hormone Replacement.Endocrine reviews · 2022Article
- Lifestyle is associated with thyroid function in subclinical hypothyroidism: a cross-sectional study.BMC endocrine disorders · 2021Article
- What Is the Quality of Life in Patients Treated with Levothyroxine for Hypothyroidism and How Are We Measuring It? A Critical, Narrative Review.Journal of clinical medicine · 2021Review
- Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.European thyroid journal · 2021Article
- The Role of Illness-Related Beliefs in Depressive, Anxiety, and Anger Symptoms: An On-line Survey in Women With Hypothyroidism.Frontiers in psychiatry · 2021Article
- The effectiveness of cognitive- behavioral therapy on quality of life in women with hypothyroidism in the reproductive age: a randomized controlled trial.Thyroid research · 2020Article
- Exercise training-induced changes in metabolic syndrome parameters, carotid wall thickness, and thyroid function in middle-aged women with subclinical hypothyroidism.Pflugers Archiv : European journal of physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training. SUBJECTS AND
methodsIn the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL. In the second phase, a randomized clinical trial was conducted where only women with sHT were randomly divided into two groups: sHT-Tr (n = 10) - participants that performed an exercise program - and sHT-Sed (n = 10) - controls. Exercise training consisted of 60 minutes of aerobic activities (bike and treadmill), three times a week, for 16 weeks. The HRQoL was assessed by the SF-36 questionnaire in the early and at the end of four months.
resultsWomen with sHT had lower scores on functional capacity domain in relation to the euthyroid ones (770 ± 23.0 vs. 88.8 ± 14.6; p = 0.020). The sHT-Tr group improved functional capacity, general health, emotional aspects, mental and physical component of HRQoL after training period, while the sHT-Sed group showed no significant changes.
conclusionAfter 16 weeks of aerobic exercise training, there were remarkable improvements in HRQoL in women with sHT.
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