Trial reportPloS one2018
Transcatheter aortic valve replacement (TAVR) leads to an increase in the subendocardial viability ratio assessed by pulse wave analysis.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Association between subendocardial viability ratio and cardiovascular events: a cohort study in a Chinese community-based population.BMJ open · 2025Observational
- Research Progress and Clinical Value of Subendocardial Viability Ratio.Journal of the American Heart Association · 2024Review
- A new integrative approach to assess aortic stenosis burden and predict objective functional improvement after TAVR.Frontiers in cardiovascular medicine · 2023Article
- Arterial stiffness in aortic stenosis - complex clinical and prognostic implications.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2022Review
- Arterial Stiffness, Subendocardial Impairment, and 30-Day Readmission in Heart Failure Older Patients.Frontiers in cardiovascular medicine · 2022Article
- Immediate reduction in left ventricular ejection time following TAVI is associated with improved quality of life.Frontiers in cardiovascular medicine · 2022Article
- Arterial Stiffness in Aortic Stenosis and the Impact of Aortic Valve Replacement.Vascular health and risk management · 2022Article
- The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.PloS one · 2021Article
- Cardiovascular Risk Factors and Hemodynamic Measures as Determinants of Increased Arterial Stiffness Following Surgical Aortic Valve Replacement.Frontiers in cardiovascular medicine · 2021Article
- Impaired subendocardial perfusion in patients with metabolic syndrome.Diabetes & vascular disease researchArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulse wave analysis (PWA) is a useful tool for non-invasive assessment of central cardiac measures as subendocardial perfusion (Subendocardial Viability Ratio, SEVR) or contractility (dP/dtmax). The immediate influence of transcatheter aortic valve replacement (TAVR) on these indices has not been investigated yet.
methodsWe prospectively enrolled 40 patients presenting with severe aortic stenosis receiving TAVR. Central pressure curves were derived from radial and carotid sites using PWA up to 2 days before and 7 days after TAVR. Parameters were compared between peripheral measurement sites. Changes in SEVR, dP/dtmax and in indices of vascular stiffness were assessed. Additionally, association of these variables with clinical outcome was evaluated during a 12-month follow-up.
resultsCentral waveform parameters were comparable between measurement sites. SEVR, but not dP/dtmax, augmentation Index (AIx) or augmentation pressure height (AGPH) correlated significantly with disease severity reflected by peak transvalvular velocity and mean transvalvular pressure gradient over the aortic valve (Vmax, ΔPm) [r = -0.372,p = 0.029 for Vmax and r = -0.371,p = 0.021 for ΔPm]. Vmax decreased from 4.5m/s (IQR:4.1-5.0) to 2.2m/s (IQR:1.9-2.7), (p<0.001). This resulted in a significant increase in SEVR [135.3%(IQR:115.5-150.8) vs. 140.3%(IQR:123.0-172.5),p = 0.039] and dP/dtmax [666mmHg(IQR:489-891) vs. 927mmHg(IQR:693-1092),p<0.001], and a reduction in AIx [154.8%(IQR:138.3-171.0) vs. 133.5%(IQR:128.3-151.8),p<0.001] and AGPH [34.1%(IQR:26.8-39.0) vs. 25.0%(IQR 21.8-33.7),p = 0.002], confirming the beneficial effects of replacing the stenotic valve. No association of these parameters could be revealed with outcome.
conclusionsPWA is suitable for assessing coronary microcirculation and contractility mirrored by SEVR and maxdP/dt in the setting of aortic stenosis. PWA parameters attributed to vascular properties should be interpreted with caution.
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