Evidence map›Paper›PMID 30462700›Full record

ArticlePloS one2018

Prescription and non-prescription antibiotic dispensing practices in part I and part II pharmacies in Moshi Municipality, Kilimanjaro Region in Tanzania: A simulated clients approach.

Pius G Horumpende, Tolbert B Sonda, Marco van Zwetselaar, Magreth L Antony, Filemon F Tenu, Charles E Mwanziva, Elichilia R Shao, Stephen E Mshana, Blandina T Mmbaga, Jaffu O Chilongola

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 4 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Microorganisms · 2023
    Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Pius G HorumpendeDepartment of Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, Moshi, Tanzania.ORCID 0000-0003-1241-6997
Tolbert B SondaDepartment of Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Marco van ZwetselaarKilimanjaro Clinical Research Institute, Moshi, Tanzania.ORCID 0000-0002-5953-0060
Magreth L AntonySection of HIV Viral Load and Early Infant Diagnostics, National Health Laboratory Quality Assurance and Training Centre, Dar es Salaam, Tanzania.
Filemon F TenuDepartment of Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Charles E MwanzivaDepartment of Preventive Medicine and Research, Lugalo General Military Hospital and Military College of Medical Sciences (MCMS), Dar es Salaam, Tanzania.
Elichilia R ShaoDepartment of Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Stephen E MshanaDepartment of Microbiology and Immunology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Blandina T MmbagaKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Jaffu O ChilongolaDepartment of Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Kilimanjaro Christian Medical Centre · TZCatholic University of Health and Allied Sciences · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic dispensing without a prescription poses a threat to public health as it leads to excessive antibiotic consumption. Inappropriate antibiotic availability to the community has been documented to be amongst drivers of antimicrobial resistance emergence. Community pharmacies are a source of antibiotics in low and middle-income countries (LMICs). We aimed at assessing antibiotic dispensing practices by community pharmacy retailers in Moshi urban, Kilimanjaro, Tanzania and recommend interventions to improve practice. Using a Simulated Client (SC) Method, an observational cross-sectional survey of antibiotic dispensing practices was conducted from 10th June to 10th July 2017. Data analysis was done using Stata 13 (StataCorp, College Station, TX, USA). A total of 82 pharmacies were visited. Part I pharmacies were 26 (31.71%) and 56 (68.29%) were part II. Overall 92.3% (95% CI 77.8-97.6) of retailers dispensed antibiotics without prescriptions. The antibiotics most commonly dispensed without a prescription were ampiclox for cough (3 encounters) and azithromycin for painful urination (3 encounters). An oral third generation cephalosporin (cefixime) was dispensed once for painful urination without prescription by a part I pharmacy retailer. Out of 21, 15(71.43%) prescriptions with incomplete doses were accepted and had antibiotics dispensed. Out of 68, 4(5.9%) retailers gave instructions for medicine use voluntarily. None of the retailers voluntarily explained drug side-effects. In Moshi pharmacies, a high proportion of antibiotics are sold and dispensed without prescriptions. Instructions for medicine use are rarely given and none of the retailers explain side effects. These findings support the need for a legislative enforcement of prescription-only antibiotic dispensing rules and regulations. Initiation of clinician and community antibiotic stewardship and educational programs on proper antibiotic use to both pharmacists and public by the regulatory bodies are highly needed.

Indexed as

PharmacistsAnti-Bacterial AgentsAzithromycinCefiximeCommunity Pharmacy ServicesCross-Sectional StudiesDrug PrescriptionsDrug-Related Side Effects and Adverse ReactionsFemaleHumansMaleSurveys and QuestionnairesTanzaniaAnti-Bacterial AgentsAzithromycinCefixime

Identifiers

PMID30462700
PMCPMC6248976
OpenAlexW2901854350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.