SynthesisPloS one2018
Scientific evidence for the management of dentin caries lesions in pediatric dentistry: A systematic review and network meta-analysis.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Do systematic reviews of non- and micro-invasive treatment for caries lesions in children and adolescents adhere to the PRISMA reporting guidelines? A meta-research.Evidence-based dentistry · 2026Pooled it
- Mapping Systematic Reviews on the Management of Dental Caries in Primary Teeth: A Meta-research.Current pediatric reviews · 2026Pooled it
- Which management strategy has the highest success rate for occlusoproximal caries lesions in primary molars? A systematic review and network meta-analysis.Evidence-based dentistry · 2025Pooled it
- Management strategies for posterior deciduous and permanent teeth with developmental defects of enamel presenting post-eruptive breakdown or atypical cavitated carious lesions: systematic review and meta-analysis.Evidence-based dentistry · 2025Pooled it
- Success rate of Hall Technique for restoring carious primary molars - systematic review and meta-analysis.Evidence-based dentistry · 2025Pooled it
- Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Pooled it
- Economic Evaluation of ART and Hall in Primary Molars.BMC oral health · 2025Trial
- Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial.International dental journal · 2025Trial
- Selective outcome reporting in paediatric dentistry restorative treatment randomised clinical trials-A meta-research.International journal of paediatric dentistry · 2023Trial
- Survival rate of the Hall technique compared with resin composite restoration in multi-surface cavities in primary teeth: a 1-year randomized clinical trial.Journal of applied oral science : revista FOB · 2023Trial
- Use of rubber dam versus cotton roll isolation on composite resin restorations' survival in primary molars: 2-year results from a non-inferiority clinical trial.BMC oral health · 2022Trial
- Atraumatic restorative treatment compared to the Hall Technique for occluso-proximal carious lesions in primary molars; 36-month follow-up of a randomised control trial in a school setting.BMC oral health · 2020Trial
- Microstructural Analysis of Carious Lesion Progression Beneath Hall Technique and Conventional Stainless-Steel Crowns in Children.International journal of paediatric dentistry · 2026Article
- Effect of minimal intervention on carious lesions in primary teeth. An Umbrella review.Frontiers in dental medicine · 2025Review
- CONSORT statement adherence and risk of bias in randomized controlled trials on deep caries management: a meta-research.BMC oral health · 2024Article
- Evaluating Glass Ionomer Cement Longevity in the Primary and Permanent Teeth-An Umbrella Review.Journal of functional biomaterials · 2024Review
- The clinical success of ART restorations and Hall technique in primary molars: a randomized 18-month follow-up study.Restorative dentistry & endodontics · 2023Article
- Dentists' Self-evaluated Ability in Diagnosing and Updating About Pulpotomy.International dental journal · 2023Article
- Hall technique for primary teeth: A systematic review and meta-analysis.The Japanese dental science review · 2022Review
- Clinical Effectiveness of Restorative Materials for the Restoration of Carious Primary Teeth: An Umbrella Review.Journal of clinical medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA systematic quantitative evaluation of the available evidence of the treatment for caries lesions in primary teeth that considers how different caries progressions lead to the need for distinct interventions might provide additional useful information for clinical evidence-based decision making. The aim of this systematic review and network meta-analysis was to verify the effect of the treatments on caries lesion arrestment (CLA) or the success rate (SR) of dentin caries lesion treatments in the primary teeth.
methodsA search was conducted using the MEDLINE/PubMed, Web of Science and Scopus databases through December 2017. The primary search terms used in combination were primary teeth, caries lesion and restoration. The grey literature was also screened, as were the reference lists of eligible studies. A search of prospective studies with at least 12 months of follow up that compared different techniques was performed. The exclusion criteria were the absence of a comparison group; no evaluation of different restorative techniques; the evaluation of other outcomes unrelated to this review; and the recruitment of specific patient. The risk of bias was evaluated by the tools: the Cochrane Handbook for Systematic Reviews of Interventions and ROBINS-I. A network meta-analyses and meta-analyses were conducted considering CLA or SR as outcomes according to the surface involved and the depth of progression.
resultsOf the 1671 potentially eligible studies, 15 were included. For occlusal surfaces, only two studies presented data regarding the outer half of the dentin, with conventional restorative treatment (CRT) using composite resin showing superior results; five studies presented data regarding the depth of caries lesions, and CRT with compomer resulted in the best results. Seven studies considered occlusoproximal surfaces, and the Hall technique showed the best SR among the evaluated treatments. Finally, two annual applications of silver diamine fluoride showed the best nonrestorative approach to arrest caries lesions on occlusal and smooth surfaces. DISCUSSION/
conclusionsThe treatments for dentin caries lesions in primary teeth depend on the depth of progression and the surface involved. However, few of the included studies provided evidence to strongly recommend the best treatment option. OTHER: Funding: FAPESP; Systematic review registration number-PROSPERO CRD42016037784.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.