Evidence map›Paper›PMID 30462532›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease.

Sanae Sakami, Yoshikazu Imanishi, Krzysztof Palczewski

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Immunology of Retinitis Pigmentosa and Gene Therapy-Associated Uveitis.Cold Spring Harbor perspectives in medicine · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Nestin Regulates Müller Glia Proliferation After Retinal Injury.Investigative ophthalmology & visual science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sanae SakamiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Yoshikazu ImanishiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Krzysztof PalczewskiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Case Western Reserve University · US

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
A two-photon ophthalmoscope for human retinal imaging and functional testingU01EY025451 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2015 to 2019
$3.2M
Photoreceptor dysfunction associated with rhodopsin mislocalizationR01EY028884 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI IMANISHI, YOSHIKAZU · 2018 to 2021
$1.6M
Leica SP8 Confocal with Hyvolution2 DeconvolutionS10OD024996 · OD · CASE WESTERN RESERVE UNIVERSITY · PI IMANISHI, YOSHIKAZU · 2018 to 2018
$594k
NEI NIH HHS R01 EY009339NEI NIH HHS R01 EY028884NEI NIH HHS R24 EY027283NEI NIH HHS U01 EY025451NIH HHS S10 OD024996
6 · The paper itself

Abstract

Retinitis pigmentosa is a devastating, blinding disorder that affects 1 in 4000 people worldwide. During the progression of the disorder, phagocytic clearance of dead photoreceptor cell bodies has a protective role by preventing additional retinal damage from accumulation of cellular debris. However, the cells responsible for the clearance remain unidentified. Taking advantage of a mouse model of retinitis pigmentosa ( Rho

Indexed as

AnimalsDisease Models, AnimalMacrophagesMiceMice, Inbred C57BLNeurogliaPhagocytosisRetinaRetinal Cone Photoreceptor CellsRetinal DegenerationRetinal Rod Photoreceptor CellsRetinitis Pigmentosaphagocytosisretinitis pigmentosarhodopsinrod photoreceptors

Identifiers

PMID30462532
PMCPMC6404573
OpenAlexW2900846110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.