ArticleCerebral cortex (New York, N.Y. : 1991)2019
Person-Based Brain Morphometric Similarity is Heritable and Correlates With Biological Features.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.The American journal of psychiatry · 2025Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.Translational psychiatry · 2026Article
- Personalized Estimates of Brain Cortical Structural Similarity in Major Depressive Disorder: Evidence from a Multi-Site Neuroimaging Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Structural brain variability in recent-onset and chronic schizophrenia: evidence from person-based similarity index analysis.Acta neuropsychiatrica · 2025Article
- Parsing heterogeneity in global and local white matter integrity at different stages across the psychosis continuum.Schizophrenia (Heidelberg, Germany) · 2024Article
- Multimodal Neuroimaging Summary Scores as Neurobiological Markers of Psychosis.Schizophrenia bulletin · 2024Article
- Temporal Interactions between Maintenance of Cerebral Cortex Thickness and Physical Activity from an Individual Person Micro-Longitudinal Perspective and Implications for Precision Medicine.Journal of personalized medicine · 2024Article
- LearningBrain sciences · 2023Article
- Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance.Molecular autism · 2023Article
- Morphometric dis-similarity between cortical and subcortical areas underlies cognitive function and psychiatric symptomatology: a preadolescence study from ABCD.Molecular psychiatry · 2023Article
- Morphometric similarity network alterations in COVID-19 survivors correlate with behavioral features and transcriptional signatures.NeuroImage. Clinical · 2023Article
- Personalized estimates of morphometric similarity in multiple sclerosis and neuromyelitis optica spectrum disorders.NeuroImage. Clinical · 2023Article
- Cortical gradient of a human functional similarity network captured by the geometry of cytoarchitectonic organization.Communications biology · 2022Article
- Comparing personalized brain-based and genetic risk scores for major depressive disorder in large population samples of adults and adolescents.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis.Translational psychiatry · 2022Article
- Person-Based Similarity Index for Cognition and Its Neural Correlates in Late Adulthood: Implications for Cognitive Reserve.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.Frontiers in aging neuroscience · 2022Article
- Brain morphometric similarity and flexibility.Cerebral cortex communications · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The characterization of the functional significance of interindividual variation in brain morphometry is a core aim of cognitive neuroscience. Prior research has focused on interindividual variation at the level of regional brain measures thus overlooking the fact that each individual brain is a person-specific ensemble of interdependent regions. To expand this line of inquiry we introduce the person-based similarity index (PBSI) for brain morphometry. The conceptual unit of the PBSI is the individual person's brain structural profile which considers all relevant morphometric measures as features of a single vector. In 2 independent cohorts (total of 1756 healthy participants), we demonstrate the foundational validity of this approach by affirming that the PBSI scores for subcortical volume and cortical thickness in healthy individuals differ between men and women, are heritable, and robust to variation in neuroimaging parameters, sample composition, and regional brain morphometry. Moreover, the PBSI scores correlate with age, body mass index, and fluid intelligence. Collectively, these results suggest that the person-based measures of brain morphometry are biologically and functionally meaningful and have the potential to advance the study of human variation in multivariate brain imaging phenotypes in healthy and clinical populations.
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