Evidence map›Paper›PMID 30462190›Full record

ArticleBioinformatics (Oxford, England)2019

ProteomicsBrowser: MS/proteomics data visualization and investigation.

Gang Peng, Rashaun Wilson, Yishuo Tang, TuKiet T Lam, Angus C Nairn, Kenneth Williams, Hongyu Zhao

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gang PengDepartment of Biostatistics, School of Medicine, Yale University, New Haven, CT, USA.
Rashaun WilsonDepartment of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA.
Yishuo TangDepartment of Genetics, School of Medicine, Yale University, New Haven, CT, USA.
TuKiet T LamDepartment of Molecular Biophysics and Biochemistry, School of Medicine, Yale University, New Haven, CT, USA.
Angus C NairnDepartment of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA.
Kenneth WilliamsDepartment of Molecular Biophysics and Biochemistry, School of Medicine, Yale University, New Haven, CT, USA.
Hongyu ZhaoDepartment of Biostatistics, School of Medicine, Yale University, New Haven, CT, USA.

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1M
NIDA NIH HHS P30 DA018343
6 · The paper itself

Abstract

summaryLarge-scale, quantitative proteomics data are being generated at ever increasing rates by high-throughput, mass spectrometry technologies. However, due to the complexity of these large datasets as well as the increasing numbers of post-translational modifications (PTMs) that are being identified, developing effective methods for proteomic visualization has been challenging. ProteomicsBrowser was designed to meet this need for comprehensive data visualization. Using peptide information files exported from mass spectrometry search engines or quantitative tools as input, the peptide sequences are aligned to an internal protein database such as UniProtKB. Each identified peptide ion including those with PTMs is then visualized along the parent protein in the Browser. A unique property of ProteomicsBrowser is the ability to combine overlapping peptides in different ways to focus analysis of sequence coverage, charge state or PTMs. ProteomicsBrowser includes other useful functions, such as a data filtering tool and basic statistical analyses to qualify quantitative data. AVAILABILITY AND IMPLEMENTATION: ProteomicsBrowser is implemented in Java8 and is available at https://medicine.yale.edu/keck/nida/proteomicsbrowser.aspx and https://github.com/peng-gang/ProteomicsBrowser. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

Data VisualizationProteomicsDatabases, ProteinMass SpectrometryProtein Processing, Post-TranslationalSoftware

Identifiers

PMID30462190
PMCPMC6596887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.