Evidence map›Paper›PMID 30462164›Full record

ReviewBriefings in bioinformatics2019

Harmonizing semantic annotations for computational models in biology.

Maxwell Lewis Neal, Matthias König, David Nickerson, Göksel Mısırlı, Reza Kalbasi, Andreas Dräger, Koray Atalag, Vijayalakshmi Chelliah, Michael T Cooling, Daniel L Cook and 18 more

Abstract readReview
In one paragraph

Review in Briefings in bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. FAIRification of computational models in biology.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Making PBPK models more reproducible in practice.Briefings in bioinformatics · 2024
    Article
  11. Genome-scale model ofMicrobiology spectrum · 2024
    Article
  12. BioKC: a collaborative platform for curation and annotation of molecular interactions.Database : the journal of biological databases and curation · 2024
    Article
  13. Article
  14. An automated model annotation system (AMAS) for SBML models.Bioinformatics (Oxford, England) · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Maxwell Lewis NealSeattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, USA.
Matthias KönigDepartment of Biology, Humboldt-University Berlin, Institute for Theoretical Biology, Berlin, Germany.
David NickersonAuckland Bioengineering Institute, University of Auckland, Auckland, NZ.
Göksel MısırlıSchool of Computing and Mathematics, Keele University, Keele, UK.
Reza KalbasiAuckland Bioengineering Institute, University of Auckland, Auckland, NZ.
Andreas DrägerComputational Systems Biology of Infection and Antimicrobial-Resistant Pathogens, Center for Bioinformatics Tübingen (ZBIT), University of Tübingen, Tübingen, Germany.
Koray AtalagAuckland Bioengineering Institute, University of Auckland, Auckland, NZ.
Vijayalakshmi ChelliahEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
Michael T CoolingAuckland Bioengineering Institute, University of Auckland, Auckland, NZ.
Daniel L CookDepartment of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Sharon CrookSchool of Mathematical and Statistical Sciences, Arizona State University, Tempe, USA.
Miguel de AlbaGerman Federal Institute for Risk Assessment, Berlin, Germany.
Samuel H FriedmanOpto-Knowledge Systems, Inc. (OKSI), Torrance, CA, USA.
Alan GarnyAuckland Bioengineering Institute, University of Auckland, Auckland, NZ.
John H GennariDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA.
Padraig GleesonDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Martin GolebiewskiHeidelberg Institute for Theoretical Studies (HITS gGmbH), Heidelberg, Germany.
Michael HuckaDepartment of Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA, USA.
Nick JutyEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
Chris MyersDepartment of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA.
Brett G OlivierSystems Bioinformatics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Herbert M SauroDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Martin ScharmDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany.
Jacky L SnoepDepartment of Biochemistry, Stellenbosch University, Matieland, South Africa.
Vasundra TouréDepartment of Biology, Norwegian University of Science and Technology, Trondheim, Norway.
Anil WipatSchool of Computing Science, Newcastle University, Newcastle upon Tyne, UK.
Olaf WolkenhauerDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany.
Dagmar WaltemathDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany.

Funding

TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
TR&D3: Standards and Tools for Simulator Composition and Credibility portalP41EB023912 · NIBIB · UNIVERSITY OF WASHINGTON · PI Ion I. Moraru, HERBERT M. SAURO · 2018 to 2026
$11.4M
Continued Support of Essential SBML Software and Community ResourcesR01GM070923 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HUCKA, MICHAEL · 2004 to 2018
$8.0M
High Performance Simulation Libraries for Systems BiologyR01GM123032 · NIGMS · UNIVERSITY OF WASHINGTON · PI SAURO, HERBERT M. · 2017 to 2020
$1.7M
Physiological Knowledge Integration and Recombinant Modeling Via Accelerated SemaR01LM011969 · NLM · UNIVERSITY OF WASHINGTON · PI CARLSON, BRIAN E., GENNARI, JOHN H. · 2014 to 2017
$1.7M
Tools for Model Discovery, Validation and Selection in Neuroscience with NeuroMLR01MH106674 · NIMH · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI CROOK, SHARON MARIE · 2015 to 2018
$1.6M
CRCNS Data Sharing: Exchange and Evaluation of Reduced Neuron ModlesR01EB021711 · NIBIB · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI GERKIN, RICHARD C · 2015 to 2017
$390k
Biotechnology and Biological Sciences Research Council BB/G010218/1Biotechnology and Biological Sciences Research Council BBG0102181Biotechnology and Biological Sciences Research Council BB/I004637/1Biotechnology and Biological Sciences Research Council BB/M013189/1NIBIB NIH HHS P41 EB023912NIBIB NIH HHS R01 EB021711NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM070923NIGMS NIH HHS R01 GM123032NIMH NIH HHS R01 MH106674NLM NIH HHS R01 LM011969Wellcome Trust 101445
6 · The paper itself

Abstract

Life science researchers use computational models to articulate and test hypotheses about the behavior of biological systems. Semantic annotation is a critical component for enhancing the interoperability and reusability of such models as well as for the integration of the data needed for model parameterization and validation. Encoded as machine-readable links to knowledge resource terms, semantic annotations describe the computational or biological meaning of what models and data represent. These annotations help researchers find and repurpose models, accelerate model composition and enable knowledge integration across model repositories and experimental data stores. However, realizing the potential benefits of semantic annotation requires the development of model annotation standards that adhere to a community-based annotation protocol. Without such standards, tool developers must account for a variety of annotation formats and approaches, a situation that can become prohibitively cumbersome and which can defeat the purpose of linking model elements to controlled knowledge resource terms. Currently, no consensus protocol for semantic annotation exists among the larger biological modeling community. Here, we report on the landscape of current annotation practices among the COmputational Modeling in BIology NEtwork community and provide a set of recommendations for building a consensus approach to semantic annotation.

Indexed as

Biological Science DisciplinesComputer SimulationDatabases, FactualSemanticsComputational BiologyHumansSoftwarecomputational modelingdata integrationknowledge representationmodeling standardssemantic annotation

Identifiers

PMID30462164
PMCPMC6433895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.