Evidence map›Paper›PMID 30461371›Full record

ArticleJournal of neurophysiology2019

Interaction between TRPV1-expressing neurons in the hypothalamus.

Adrien J R Molinas, Lucie D Desmoulins, Brooke V Hamling, Sierra M Butcher, Imran J Anwar, Kayoko Miyata, Courtney L Enix, Courtney M Dugas, Ryousuke Satou, Andrei V Derbenev and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. TRP Channels in Stroke.Neuroscience bulletin · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors.International journal of environmental research and public health · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022
    Review
  17. Article
  18. Review
  19. Distribution and Assembly of TRP Ion Channels.Advances in experimental medicine and biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Adrien J R MolinasDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Lucie D DesmoulinsDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Brooke V HamlingDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Sierra M ButcherDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Imran J AnwarDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Kayoko MiyataDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Courtney L EnixDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Courtney M DugasDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Ryousuke SatouDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.ORCID 0000-0001-6505-9722
Andrei V DerbenevDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Andrea ZsombokDepartment of Physiology, School of Medicine, Tulane University , New Orleans, Louisiana.
Tulane University · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
Translational Research in Hypertension and Renal BiologyP30GM103337 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI NAVAR, LUIS GABRIEL · 2012 to 2016
$5.8M
TRPV1-Dependent Autonomic Control in DiabetesR01DK099598 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI ZSOMBOK, ANDREA · 2014 to 2018
$2.0M
Sympathetic control and hypertension via brainstem cannabinoid signalingR01HL122829 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI DERBENEV, ANDREI · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL122829NIDDK NIH HHS R01 DK099598NIGMS NIH HHS P30 GM103337NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel expressed in the peripheral and central nervous systems. TRPV1-dependent mechanisms take part in a wide range of physiological and pathophysiological pathways including the regulation of homeostatic functions. TRPV1 expression in the hypothalamus has been described as well as evidence that TRPV1-dependent excitatory inputs to hypothalamic preautonomic neurons are diminished in diabetic conditions. Here we aimed to determine the functional expression of TRPV1 in two hypothalamic nuclei known to be involved in the central control of metabolism and to test the hypothesis that TRPV1-expressing neurons receive TRPV1-expressing inputs. A mouse model (TRPV1

Indexed as

AnimalsAstrocytesDependovirusFemaleHypothalamusLuminescent ProteinsMaleMembrane PotentialsMice, TransgenicNeuronsPatch-Clamp TechniquesRed Fluorescent ProteinRNA, MessengerTissue Culture TechniquesTRPV Cation ChannelsLuminescent ProteinsRed Fluorescent ProteinRNA, MessengerTRPV1 protein, mouseTRPV Cation Channelscapsaicindorsomedial hypothalamic nucleusparaventricular nucleus of the hypothalamuspatch-clampTRPV1

Identifiers

PMID30461371
PMCPMC6383661
OpenAlexW2900868071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.