ArticleJournal of feline medicine and surgery2019
A specific immunoassay for detection of feline kidney injury molecule 1.
Article in Journal of feline medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Increased serum amyloid A and urinary kidney injury marker-1 concentrations in cats with pyelonephritis: a diagnostic accuracy study.The Journal of small animal practice · 2026Article
- Urinary KIM-1 as a Marker of Renal Tubular Injury Associated with Urethral Obstruction in Non-Azotemic Cats.Animals : an open access journal from MDPI · 2026Article
- Evaluation of urinary kidney injury molecule-1 in cats with chronic kidney disease.Journal of feline medicine and surgery · 2025Article
- Optical Molecular Probes for Imaging and Early Diagnosis of Acute Kidney Injury.Current medicinal chemistry · 2025Review
- Determination of the reference interval for urine kidney injury molecule-1 in 50 healthy cats.Journal of feline medicine and surgery · 2024Article
- Effect of up to 30-days of storage at different temperatures on detection of feline kidney injury molecule-1 in urine.BMC veterinary research · 2022Article
- Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease.Journal of veterinary internal medicine · 2022Article
- Renal biomarkers in cats: A review of the current status in chronic kidney disease.Journal of veterinary internal medicine · 2022Review
- Unilateral primary carcinoma of the kidney with central nervous system invasion and vertebral lysis in a cat.JFMS open reportsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to design and carry out a preliminary evaluation of a urine point-of-care test for kidney injury molecule 1 (KIM-1) in healthy and diseased cats.
methodsPart of the feline
resultsThree antibodies were assessed. Antibodies detected between 0.4 and 60 ng/ml feline KIM-1 fusion protein in the LFA. Urine samples from healthy cats yielded faint bands in the LFA corresponding to optical density (OD) values of 4.8-8.8. Samples from cats with suspected or confirmed acute kidney injury (AKI) had OD values ranging from 1.6-20.5. Urine KIM-1 varied over multiple days in cats with sepsis or urethral obstruction despite normalizing serum creatinine concentration. In tissue sections, KIM-1 antibodies labeled tubular cells with morphological features of injury. CONCLUSIONS AND RELEVANCE: A practical patient-side assay for detection of KIM-1 in feline urine has been developed. Preliminary results show marked though transient increases in cats with sepsis and urethral obstruction-associated AKI, and expression in injured tubules. Although initial data indicating that the LFA is sensitive and specific for KIM-1 in cats with AKI are promising, values associated with different types of injury, urine collection, urine storage and specific gravity need to be investigated.
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