Evidence map›Paper›PMID 30461288›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.

Clemente J Britto, Naiqian Niu, Sara Khanal, Luai Huleihel, Jose D Herazo-Maya, Alison Thompson, Maor Sauler, Martin D Slade, Lokesh Sharma, Charles S Dela Cruz and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. BPIFA1 is a secreted biomarker of differentiating human airway epithelium.Frontiers in cellular and infection microbiology · 2022
    Article
  8. Review
  9. SPLUNC1: a novel marker of cystic fibrosis exacerbations.The European respiratory journal · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Clemente J BrittoSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Naiqian NiuSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Sara KhanalSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Luai HuleihelSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Jose D Herazo-MayaSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Alison ThompsonSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Maor SaulerSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.ORCID 0000-0001-5240-7978
Martin D SladeSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Lokesh SharmaSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Charles S Dela CruzSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Naftali KaminskiSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Lauren E CohnSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine , New Haven, Connecticut.
Yale University · US

Funding

Training Translational Lung Biology and PathobiologyT32HL007778 · NHLBI · YALE UNIVERSITY · PI Erica L Herzog, NAFTALI KAMINSKI · 1994 to 2026
$14.4M
Host-Pneumococcal Interaction in the LungR01HL126094 · NHLBI · YALE UNIVERSITY · PI DELA CRUZ, CHARLES S · 2015 to 2019
$2.1M
Airway Inflammation-Related Inhibition of Disease (AIRID)R01HL081160 · NHLBI · YALE UNIVERSITY · PI COHN, LAUREN E · 2008 to 2012
$2.1M
SPLUNC1 and Neutrophilic Inflammation in Cystic FibrosisK01HL125514 · NHLBI · YALE UNIVERSITY · PI BRITTO-LEON, CLEMENTE · 2015 to 2021
$905k
MIF and DNA repair in the emphysematous lungK08HL135402 · NHLBI · YALE UNIVERSITY · PI SAULER, MAOR · 2017 to 2021
$842k
Immune Regulation in the Respiratory Tract by the Epithelial Protein PLUNCR21AI083475 · NIAID · YALE UNIVERSITY · PI COHN, LAUREN E · 2009 to 2010
$455k
NHLBI NIH HHS K01 HL125514NHLBI NIH HHS K08 HL135402NHLBI NIH HHS R01 HL081160NHLBI NIH HHS R01 HL126094NHLBI NIH HHS T32 HL007778NIAID NIH HHS R21 AI083475
6 · The paper itself

Abstract

Bpifa1 (BPI fold-containing group A member 1) is an airway host-protective protein with immunomodulatory properties that binds to LPS and is regulated by infectious and inflammatory signals. Differential expression of Bpifa1 has been widely reported in lung disease, yet the biological significance of this observation is unclear. We sought to understand the role of Bpifa1 fluctuations in modulating lung inflammation. We treated wild-type (WT) and Bpifa1

Indexed as

Acute DiseaseAnimalsGlycoproteinsInflammationLipopolysaccharidesLungMice, Inbred C57BLNeutrophil InfiltrationPhosphoproteinsBpifa1 protein, mouseGlycoproteinsLipopolysaccharidesPhosphoproteins

Identifiers

PMID30461288
PMCPMC6397348
OpenAlexW2901345847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.