ArticleMicrobial biotechnology2019
Engineered cell-to-cell signalling within growing bacterial cellulose pellicles.
Article in Microbial biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Bacterial Species in Engineered Living Materials: Strategies and Future Directions.Microbial biotechnology · 2025Review
- Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression.Nature biotechnology · 2025Article
- Modulating Microbial Materials - Engineering Bacterial Cellulose with Synthetic Biology.ACS synthetic biology · 2024Review
- Accelerating Genetic Sensor Development, Scale-up, and Deployment Using Synthetic Biology.Biodesign research · 2024Article
- From Nature to Lab: Sustainable Bacterial Cellulose Production and Modification with Synthetic Biology.Polymers · 2023Review
- Engineered living materials grown from programmableMaterials today. Bio · 2023Article
- Engineering living and regenerative fungal-bacterial biocomposite structures.Nature materials · 2022Article
- When microbial biotechnology meets material engineering.Microbial biotechnology · 2022Article
- Bacterial cellulose spheroids as building blocks for 3D and patterned living materials and for regeneration.Nature communications · 2021Article
- Hybrid Living Capsules Autonomously Produced by Engineered Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Living materials with programmable functionalities grown from engineered microbial co-cultures.Nature materials · 2021Article
- On the way toward regulatable expression systems in acetic acid bacteria: target gene expression and use cases.Applied microbiology and biotechnology · 2021Review
- Engineering Bacterial Cellulose by Synthetic Biology.International journal of molecular sciences · 2020Review
- Spiral Honeycomb Microstructured Bacterial Cellulose for Increased Strength and Toughness.ACS applied materials & interfaces · 2020Article
- Towards control of cellulose biosynthesis by Komagataeibacter using systems-level and strain engineering strategies: current progress and perspectives.Applied microbiology and biotechnology · 2020Review
- Engineered cell-to-cell signalling within growing bacterial cellulose pellicles.Microbial biotechnology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial cellulose is a strong and flexible biomaterial produced at high yields by Acetobacter species and has applications in health care, biotechnology and electronics. Naturally, bacterial cellulose grows as a large unstructured polymer network around the bacteria that produce it, and tools to enable these bacteria to respond to different locations are required to grow more complex structured materials. Here, we introduce engineered cell-to-cell communication into a bacterial cellulose-producing strain of Komagataeibacter rhaeticus to enable different cells to detect their proximity within growing material and trigger differential gene expression in response. Using synthetic biology tools, we engineer Sender and Receiver strains of K. rhaeticus to produce and respond to the diffusible signalling molecule, acyl-homoserine lactone. We demonstrate that communication can occur both within and between growing pellicles and use this in a boundary detection experiment, where spliced and joined pellicles sense and reveal their original boundary. This work sets the basis for synthetic cell-to-cell communication within bacterial cellulose and is an important step forward for pattern formation within engineered living materials.
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Registered trials
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